血清CysC联合β_2-MG检测在诊断肾脏疾病中的应用  

The clinical diagnostic application of serum Cys C and β_2- MG in early detection of kidney diseases

作　　者：潘顺文[1] 代群[2] 廖媛[1] 周莉[1] 凌小强[1] 

机构地区：[1]中山大学附属第三医院检验科,广东广州510630 [2]中山大学附属第三医院儿科,广东广州510630

出　　处：《中国卫生检验杂志》2014年第21期3108-3110,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的检测血清胱抑素C(Cys C)和β2-微球蛋白(β2-MG)在肾脏疾病中的表达水平,分析其在诊断中的应用价值。方法采用免疫透射比浊法测定149例肾病患者中血清Cys C和β2-MG的浓度,并分析其与血清中尿素氮(BUN)和肌酐(Cr)的相关性。结果肾病组血清Cys C含量(4.40 mg/L±2.01 mg/L)高于健康对照组Cys C含量(0.82 mg/L±0.17 mg/L)(P<0.01);肾病组血清β2-MG含量(16.84 mg/L±11.60 mg/L)高于对照组β2-MG含量为(1.75 mg/L±0.43 mg/L)(P<0.01)。肾病组血清Cys C、β2-MG表达水平与血清BUN、Cr呈正相关(P<0.05)。结论联合检测血清Cys C和β2-MG可以作为早期肾损伤诊断的指标。Objective To explore the diagnostic value of by detecting the expressing levels of cystatin C （CysC） and β2 micro- globulin（ β2 - MG） in patients with kidney disease. Methods One hundred and forty - nine patients with kidney disease were enrolled in the present study. Concentrations of serum CysC and β2 - MG were detected by a latex turbidmetric immunoassay. Then the correlation between CysC and β2 - MG and renal functional index （blood urea nitrogen（BUN） and creatinine（Cr） ） was analyzed. Results Compared to the control group （0.82 ±0.17 mg/L）, the expression of CysC is significantly higher in experimental group（4.40 ± 2.01 mg/L） （ P 〈 0.01 ）. β2 - MG expression of the experimental group （ 16.84 ± 11.60 mg/L） is significantly higher than that of the control group （ 1.75 ±0.43 mg/L） （ P 〈 0.01 ）. Serum CysC and β2 - MG levels in patients with kidney diseases were positively correlated with renal functional index（ BUN and Cr） respectively. Conclusion The combined detection CysC and β2 - MG might be as a marker in the early diagnosis of kidney diseases.

关 键 词：血清胱抑素C Β2-微球蛋白 免疫透射比浊法 肾脏疾病 早期诊断 

分 类 号：R446.6[医药卫生—诊断学]