中老年2型糖尿病患者血尿酸与颈动脉粥样硬化的相关性分析  

Correlation analysis between serum uric acid and carotid atherosclerosis in middle-and oldage type 2 diabetes mellitus patients

作　　者：王凯亮[1] 韩旸[1] 张军[1] 李洪梅[1] 

机构地区：[1]北京煤炭总医院内分泌科,北京100028

出　　处：《中国医刊》2014年第11期28-30,共3页Chinese Journal of Medicine

摘　　要：目的探讨中老年2型糖尿病(T2DM)患者血清尿酸水平与颈动脉粥样硬化的相关性。方法选择住院的中老年2型糖尿病患者210例,根据颈动脉内-中膜厚度(IMT),分为颈动脉内膜正常组(A组)和颈动脉粥样硬化组(B组),比较两组间的临床资料,并对颈动脉粥样硬化危险因素进行Logistic回归分析。结果 男性高尿酸血症的患病率高于女性。男、女患者B组在年龄、糖尿病病程、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、血清尿酸(SUA)水平均高于A组。Logistic回归分析表明血清尿酸水平、年龄,糖尿病病程、LDL-C是中老年2型糖尿病患者颈动脉粥样硬化的危险因素。结论 中老年2型糖尿病患者血尿酸水平升高是颈动脉粥样硬化的独立危险因素。Objective To observe the relationship between serum uric acid and carotid atherosclerosis in middle- and old-age patients with type 2 diabetes mellitus. Method 210 middle- and old-age patients with type 2 diabetes melli- tus in hospital were collected . They were divided into two groups according to intima-media thickness of carotid ：A group： without atherosclerosis, B group： with atherosclerosis. The clinical characteristics were compared between the two groups. The risk factors of carotid atherosclerosis were analyzed by logistic regressionanalysis. Result The SUA, age, course of diabetes, TC, LDL-C in group A were all higher than in group B with significant differences, Logisticre- gerssion analysis showed that age, course of diabetes, SUA, LDL-C were risk factors of carotid atherusclerosis in mid- dle and old-age type 2 diabetes mellitus. Conclusion Elevated SUA level is closely related to carotid atherosclerosis in middle-and old-age type 2 diabetes mellitus patients.

关 键 词：2型糖尿病 血管并发症 中老年 

分 类 号：R587.1[医药卫生—内分泌]