类风湿因子、抗环瓜氨酸肽抗体与抗角蛋白抗体联合测定对类风湿性关节炎诊断价值  

Combined detection rheumatoid factor、anti-cyclic citrullinated peptide antibody and Anti-keratin Antibody in the diagnosis of rheumatoid arthritis

作　　者：陈建平[1] 杨曙梅[1] 杨春兰[1] 祝文彩[1] 

机构地区：[1]江苏省南通市南通大学附属医院检验科,江苏南通226001

出　　处：《医学检验与临床》2014年第5期22-24,共3页Medical Laboratory Science and Clinics

摘　　要：目的：本文旨在探讨联合测定类风湿因子（RF）、抗环瓜氨酸肽抗体（Anti-CCP）及抗角蛋白抗体（AKA）在诊断类风湿性关节炎（RA）中的应用价值。方法：分别运用免疫速率散射比浊法、化学发光法及间接免疫荧光法检测132例类RA患者及51例非RA患者血清中的RF、Anti-CCP及AKA。结果：RF对RA敏感性为78.0%，特异性为64.7%，阳性预测值85.1%；Anti-CCP对RA敏感性为75.0%，特异性为88.2%，阳性预测值94.2%；AKA对RA敏感性为75.8%，特异性为86.3%，阳性预测值93.5%；RF、Anti-CCP及AKA联合检测诊断RA的敏感性为63.6%，特异性为96.1%，阳性预测值97.7%。结论： RF在RA诊断中敏感性较Anti-CCP及AKA高，但特异性较Anti-CCP及AKA低；RF、Anti-CCP及AKA联合检测的应用，更有助于类风湿关节炎的早期诊断。Objective：In the study, we clarity the combined detection of rheumatoid factor（RF）、anti-cyclic citrullinated peptide antibody（Anti-CCP） and anti-keratin antibody（AKA） in the diagnosis of rheumatoid arthritis（RA）.Methods：132 patients with RA, 51 patients with other arthritis. RF was measured by immune rate nephelometry. Anti-CCP was measured by chemiluminescence immunoassay. Indirect Immunofluorescence assay was used to detect AKA.Results：The diagnostic sensitivity of RF for RA was 78.0% and the specificity was 64.7%. Whereas the diagnostic sensitivity of Anti-CCP for RA was 75.0% and the specificity was 88.2%. The diagnostic sensitivity of AKA for RA was 75.8% and the specificity was 86.3%. The combined detection of RF、Anti-CCP and AKA had a sensitivity of 63.6%% and the specificity of 96.1%.Conclusions：The results suggest that for diagnosis RA, the sensitivity of RF is better than Anti-CCP and AKA, whereas the specificity of Anti-CCP and AKA is better than RF. Combination of RF、Anti-CCP and AKA may be more helpful in early cliagnosis of RA patients.

关 键 词：类风湿性关节炎 类风湿因子 抗环瓜氨酸肽抗体 抗角蛋白抗体 

分 类 号：R593.22[医药卫生—内科学]