晚期糖基化终末产物对术后下肢深静脉血栓的影响  

The impact of advanced glycation end products on post-thrombotic syndrome

作　　者：庞杰[1] 刘磊[1] 

机构地区：[1]河北省保定市第二医院骨科,河北保定071051

出　　处：《临床和实验医学杂志》2014年第21期1805-1807,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨晚期糖基化终末产物(AGEs)含量变化与下肢深静脉血栓后遗症(PTS)严重程度相关性。方法选取PTS患者44例作为PTS组(共58条静脉梗阻),应用彩色多普勒超声检测患者患处的病变情况及血流动力学情况;选取下肢深静脉栓塞经过治疗疗后未患PTS的患者30例作为非PTS组;另选择正常体检者作为30例作为对照组,检测所有对象血清中AGEs含量,观察其变化特征。结果 PTS组血清AGEs含量明显高于非PTS组及对照组(P<0.05);非PTS组血清AGEs含量明显高于对照组(P<0.05)。全肢型血清AGEs含量明显高于局段发作的栓塞患者(P<0.05);在全肢型中,I型患者血清AGEs含量明显高于II A及II B型(P<0.05),ⅡA型与ⅡB型差异无统计学意义(P>0.05)。血流动力学严重障碍患者血清AGEs含量明显高于中度及轻度障碍患者(P<0.05);血流动力学中度障碍患者血清AGEs含量明显高于轻度障碍患者(P<0.05)。结论 AGEs与PTS发生、发展及病情严重性息息相关。Objective To investigate the relationship between the changes of advanced glycation end products levels（ AGEs） in patients with post- thrombotic syndrome（ PTS） and the severities of this disease. Methods 44 patients with PTS were chose as PTS group（ there are 58 of cava obstruction）. Color doppler ultrasound was used to detect the lesion of affected part and haemodynamics. 30 patients with deep venous thrombosis that after treatment were chosen as non- PTS group and 30 normal persons served as healthy controls. The AGEs level was detected and observed the varied. Results The AGEs level in PTS group was significantly higher than that in non- PTS group. The AGEs level in non- PTS group was significantly higher than that in in healthy controls（ P〈0. 05）. The AGEs level in the person that thrombosis occurs in all places was significantly higher than that in the person that thrombosis occurs in part places（ P〈0. 05）. There were significantly higher than that in II A type and II B type（ P〈0. 05）. But there was no statistical significance between II A type and II B（ P〉0. 05）. The AGEs level in the person with severe blood disorders was significantly higher than that with moderate blood disorders（ P〈0. 05）,also the AGEs level in the person with moderate blood disorders was significantly higher than that with mild bleeding disorder（ P〈0. 05）. Conclusion The AGEs level was closely related to occurrence and development of disease.

关 键 词：AGES PTS 超声多普勒 血流动力学 

分 类 号：R654.4[医药卫生—外科学]