Phytomedicines as potential inhibitors of β amyloid aggregation: significance to Alzheimer's disease  

作　　者：N.Satheesh Kumar N.Nisha 

机构地区：[1]Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research [NIPER-H] Balanagar,Hyderabad-500037, India [2]Department of Biochemistry Aurigene Discovery Technologies, Hyderabad-500049, India

出　　处：《Chinese Journal of Natural Medicines》2014年第11期801-818,共18页中国天然药物（英文版）

基　　金：supported by the CSIR,HRDG,Government of India,New Delhi[F.No.60(0109)/13/EMR-II]

摘　　要：Throughout the history of drug development, plants have been an important source for the discovery of novel therapeutically active compounds for many diseases. The ethnopharmacological approach has provided several leads to identify potential new drugs from plant sources, including those for memory disorders. For the treatment of Alzheimer's disease the drug discovery focus shifted from cholinesterase inhibitors, to other targets primarily based on two key neuropathological hallmarks, namely the hyperphosphorylation of the tau protein resulting in the formation of neurofibrillary tangles(NFTs), and the increased formation and aggregation of amyloid-beta peptide(Aβ) derived from amyloid precursor protein(APP). The present article aims to provide a comprehensive literature survey of plants and their constituents that have been tested for Aβ aggregation, thus possibly relieving several features of Alzheimer's disease(AD).Throughout the history of drug development, plants have been an important source for the discovery of novel therapeutically active compounds for many diseases. The ethnopharmacological approach has provided several leads to identify potential new drugs from plant sources, including those for memory disorders. For the treatment of Alzheimer＇s disease the drug discovery focus shifted from cholinesterase inhibitors, to other targets primarily based on two key neuropathological hallmarks, namely the hyperphosphorylation of the tau protein resulting in the formation of neurofibrillary tangles（NFTs）, and the increased formation and aggregation of amyloid-beta peptide（Aβ） derived from amyloid precursor protein（APP）. The present article aims to provide a comprehensive literature survey of plants and their constituents that have been tested for Aβ aggregation, thus possibly relieving several features of Alzheimer＇s disease（AD）.

关 键 词：Amyloid-beta peptide Medicinal plants Thioflavin T β amyloid aggregation Plant-derived pharmaceuticals 

分 类 号：R965[医药卫生—药理学]