HIV-1感染急性期细胞因子动力学特点及其作用  

The dynamics characteristics and functions of cytokines in acute HIV-1 infection

作　　者：张彤[1] 宋静静[1] 焦艳梅[1] 吴昊[1] 

机构地区：[1]首都医科大学附属北京佑安医院感染中心,北京100069

出　　处：《中国艾滋病性病》2014年第10期786-790,共5页Chinese Journal of Aids & STD

基　　金：国家"十二五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2012ZX10004904-002-002;2012ZX10001-003;2012ZX10001-008);北京市重点实验室(BZ0089)~~

摘　　要：细胞因子在艾滋病病毒I型(HIV-1)感染的发病机制中发挥着重要作用。许多研究表明,在HIV/猴免疫缺陷病毒(SIV)感染的急性期,细胞因子可以影响几个月后的病毒调定点,而后者将影响慢性期病情进展和病毒传播。在感染急性期,早期细胞因子环境可能是疫苗研发和感染治疗的一个新靶标。文章重点对急性HIV-1/SIV感染期的细胞因子动力学和功能及其对病毒调定点的影响进行综述,这将有利于理解急性HIV-1感染期细胞因子的作用,并为防治策略的制定提供新的思路。Cytokines play a central role in the pathogenesis of HIV. A number of studies have shown that cyto- kines in acute stage of infection may affect viral set-point months later, and this is of critical importance since viral set-point during chronic HIV infection affects virus transmission and disease progression. Modulating the cytokine environment during acute HIV infection can be a target for novel approaches to develop a vaccine and therapeutics. In this review, we focus on the dynamics and functions of cytokines in acute infection of HIV/SIV, and how they af- fect virus set-point, which will help to understand the role of cytokines in HIV-1 infection and provide new insights into control strategy.

关 键 词：艾滋病病毒 猴免疫缺陷病毒 细胞因子 病毒调定点 

分 类 号：R373.9[医药卫生—病原生物学]