2011—2013年辽宁省肿瘤医院药物不良反应分析  

Analysis on adverse drug reactions in Liaoning Cancer Hospital and Institute from 2011 to 2013

作　　者：黎苏[1] 崔红霞[1] 黄丹雪[1] 刘广宣[1] 罗显峰[1] 

机构地区：[1]辽宁省肿瘤医院药学部,辽宁沈阳110042

出　　处：《现代药物与临床》2014年第10期1165-1168,共4页Drugs & Clinic

摘　　要：目的：研究辽宁省肿瘤医院药品不良反应（ADR）发生的特点与一般规律，为临床合理用药提供参考。方法对辽宁省肿瘤医院2011-2013年上报国家药品不良反应监测系统的229例有效ADR报告进行回顾性分析。结果229例ADR报告中，患者性别差异不明显，年龄主要集中在40～69岁（184例，80.35%），其中50～59岁最多（100例，43.67%）；静脉滴注给药最易引发ADR（328次，91.11%）；引起ADR的药品主要为抗肿瘤药物，顺铂为致ADR最多的药品（63例，27.51%）；血液及造血系统受累居首位（119例，51.97%）。结论临床应加强抗肿瘤药物ADR的监测与上报工作，为合理用药与患者安全做出保障。Objective To investigate the characteristics and regularity of adverse drug reaction （ADR） in Liaoning Cancer Hospital and Institute and provide the reference for rational drug use. Methods Effective ADR reports （229 cases） in Liaoning Cancer Hospital and Institute from 2011 to 2013, reported to ADR Monitoring Center of the State, were retrospectively analyzed. Results Among ADR reports （229 cases）, the difference between men and women was not obvious, and the cases mainly occurred in the age from 40 to 69 （184 cases, 80.35%）, especially from 50 to 59 （100 cases, 43.67%）. Iv injection was the most likely way to cause the ADR （328 cases, 91.11%）, the largest number of ADR reports was caused by antitumor drugs, the overwhelming majority of ADR was induced by cis-platinum （63 cases, 27.51%）. Hematological system involved in ADR was most common （119 cases, 51.97%）. Conclusion More attention should be paid on the ADR monitoring and reporting of antitumor drugs to promote clinical rational use and safe medication.

关 键 词：抗肿瘤药物 药品不良反应 合理用药 

分 类 号：R979.1[医药卫生—药品]