新型质子泵抑制剂泰妥拉唑合成的研究进展  

Progress in synthesis research of the new proton pump inhibitor tenatoprazole

作　　者：阎峰[1] 闵婕[1] 关瑾[1] 刘芷含[1] 

机构地区：[1]沈阳化工大学应用化学学院,沈阳110142

出　　处：《中国新药杂志》2014年第22期2637-2642,共6页Chinese Journal of New Drugs

基　　金：辽宁省自然基金(20092055);辽宁省教育厅科学研究一般项目(L2014160)

摘　　要：质子泵抑制剂为H+/K+-ATP酶抑制剂,用于治疗胃酸相关性疾病。泰妥拉唑是一种处于临床研究的新型质子泵抑制剂,其结构与奥美拉唑相似。依据国内外近期公开发表的44篇文献,对主要中间体2-巯基-5-甲氧基咪唑并[4,5-b]吡啶,以及泰妥拉唑合成方法的研究进展进行综述,为泰妥拉唑的合成及工业化生产提供参考价值。Proton pump inhibitors （PPIs） have been widely used in the treatment of acid-related diseases by inhibition of the H ＋/K ＋ -ATPase. Tenatoprazole is a novel PPI which is similar to the omeprazole in the chemi- cal structure and now is in clinical trials for regulatory approvals. The recent developments in methods for synthesi- zing the main intermediate 2-mercapto-5-methoxyimidazo [ 4, 5-b ] pyridine and tenatoprazole were summarized by citing 44 references, for providing reference for further research of tenatoprazole.

关 键 词：泰妥拉唑 2-巯基-5-甲氧基咪唑并[4 5-b]吡啶 质子泵抑制剂 合成 

分 类 号：R975.2[医药卫生—药品]