强化他汀治疗对冠脉慢血流患者血浆APN和HDL的影响  

Influence of intensive atorvastatin treatment on plasma APN and HDL of patients with coronary slow flow

作　　者：魏敦宏[1] 常快乐[1] 付清海[1] 

机构地区：[1]解放军第3医院医务处,陕西宝鸡721004

出　　处：《临床军医杂志》2014年第11期1107-1109,共3页Clinical Journal of Medical Officers

摘　　要：目的观察强化阿托伐他汀治疗对冠状动脉慢血流(CSF)患者血浆脂联素(APN)、高密度脂蛋白(HDL)的影响。方法将经冠脉造影检查诊断为CSF的98例患者,随机分为常规组及强化组,每组49例,常规组给予阿托伐他汀20 mg,1次/晚;强化组给予阿托伐他汀40 mg,1次/晚。观察治疗3个月后,两组患者血浆APN及HDL水平的变化。结果治疗3个月后,两组患者血浆APN及HDL水平均较治疗前明显升高,治疗前后比较,差异有统计学意义(P<0.05)。强化组与常规组比较,强化组APN及HDL水平较常规组明显升高,差异有统计学意义(P<0.05)。结论强化他汀治疗可明显提高CSF患者血浆HDL及APN水平。Objective To investigate the effects of intensive atorvastatin treatment on plasma adiponectin （APN） and high density lipoprotein （HDL） of patients with coronary slow flow （CSF）. Methods A total of 98 patients diagnosed as CSF by coronary angiography were randomly divided into moderate group （ n = 49） and intensive group （ n = 49 ）. The moderate group was given atorvastatin 20 mg and the intensive group 40 mg （ once per day）. Their APN and HDL levels were tested before and after three months. Results After three months＇ treatment, plasma APN and HDL were significantly increased in both the two groups （P 〈 O. 05）, and the increases of the intensive group were more significant than that of the moderate group （ P 〈 0.05 ）. Conclusion Intensive atorvastatin therapy may increase plasma HDL and APN levels significantly in CSF patients.

关 键 词：阿托伐他汀 冠状动脉慢血流 脂联素 高密度脂蛋白 

分 类 号：R541.9[医药卫生—心血管疾病]