Three-component synthesis and antibacterial evaluation of some novel 1,2-dihydroisoquinoline derivatives  

作　　者：Sakineh Asghari Nastaran Malekian Roya Esmaeilpour Mohammad Ahmadipour Mojtaba Mohseni 

机构地区：[1]Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran [2]Nano and Biotechnology Research Group, University of Mazandaran [3]Department of Microbiology, Faculty of Science, University of Mazandaran

出　　处：《Chinese Chemical Letters》2014年第11期1441-1444,共4页中国化学快报（英文版）

摘　　要：Isoquinoline reacts with dialkyl acetylenedicarboxylates in the presence of kojic acid or8-hydroxyquinoline to generate 1,2-dihydroisoquinoline derivatives. The simplicity, mild reaction conditions and high yields of products make it an interesting process compared to other approaches. The compounds have been analyzed for antibacterial activity against Gram negative and Gram positive bacteria. The results indicated that 1,2-dihydroisoquinolines derived from kojic acid are effective against all of the studied bacteria especially against Bacillus subtilis, while the products obtained from8-hydroxyquinoline are active only against Gram positive bacteria.Isoquinoline reacts with dialkyl acetylenedicarboxylates in the presence of kojic acid or8-hydroxyquinoline to generate 1,2-dihydroisoquinoline derivatives. The simplicity, mild reaction conditions and high yields of products make it an interesting process compared to other approaches. The compounds have been analyzed for antibacterial activity against Gram negative and Gram positive bacteria. The results indicated that 1,2-dihydroisoquinolines derived from kojic acid are effective against all of the studied bacteria especially against Bacillus subtilis, while the products obtained from8-hydroxyquinoline are active only against Gram positive bacteria.

关 键 词：Kojic acid 8-Hydroxyquinolone Dialkyl acetylenedicarboxylates 1 2-Dihydroisoquinoline Isoquinoline Antibacterial activity 

分 类 号：O626.323[理学—有机化学] TQ460.1[理学—化学]