Green synthesis of 1,2,4-thiadizoles from thioamides in water using molecular oxygen as an oxidant  

作　　者：Jin-Wu Zhao Jing-Xiu Xu Xiu-Zhen Guo 

机构地区：[1]School of Pharmacy, Guangdong Medical College

出　　处：《Chinese Chemical Letters》2014年第11期1499-1502,共4页中国化学快报（英文版）

基　　金：Guangdong Medical College(No.XK1110)for financial support

摘　　要：We present here an efficient green process for the synthesis of 1,2,4-thiadiazoles via iodine-catalyzed,oxidative dimerization of thioamides in water using molecular oxygen as a terminal oxidant. Under the optimized reaction conditions, aryl thioamides produced 3,5-diaryl-1,2,4-thiadiazoles in good to excellent yields. Alkyl thioamides and substituted thioureas could also provide corresponding 1,2,4-thiadiazole products.We present here an efficient green process for the synthesis of 1,2,4-thiadiazoles via iodine-catalyzed,oxidative dimerization of thioamides in water using molecular oxygen as a terminal oxidant. Under the optimized reaction conditions, aryl thioamides produced 3,5-diaryl-1,2,4-thiadiazoles in good to excellent yields. Alkyl thioamides and substituted thioureas could also provide corresponding 1,2,4-thiadiazole products.

关 键 词：1 2 4-Thiadizole Thioamide Water Oxygen 

分 类 号：TQ252[化学工程—有机化工]