阿托伐他汀对慢性心力衰竭患者心功能的影响  

The influence of Atorvastatin therapy on cardiac function in patients with chronic heart failure

作　　者：沙莎[1] 胡威[2] 欧阳定安[1] 易娜[1] 

机构地区：[1]长沙市第四医院心血管内二科,湖南省长沙市410006 [2]长沙市第四医院心血管内一科,湖南省长沙市410006

出　　处：《中国心血管病研究》2014年第11期1005-1007,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的 探讨阿托伐他汀对慢性心力衰竭患者心功能的影响.方法 纳入我院心血管门诊及住院的慢性心力衰竭患者139例,根据患者是否使用他汀类药物及他汀药物种类分为阿托伐他汀组（44例）、其他他汀组（48例）和无他汀组（47例）.收集并对比各组患者一般资料、血清NT-proBNP浓度及左心室舒张末期内径（LVEDD）、左心室缩短率（LVFS）、左心室射血分数（LVEF）等指标.结果 阿托伐他汀组较无他汀组血清NT-proBNP浓度显著降低[（1552＆#177;3416）pg/ml比（3771＆#177;6763）pg/ml,P＜0.01],LVEDD[（65.2＆#177;8.9）mm比（70.7＆#177; 10.9）mm,P＜0.05]和LVEF[（33.2＆#177; 12.6）％比（28.2＆#177;9.6）％,P＜0.05]显著降低.其他他汀组与无他汀组相比,血清NT-proBNP浓度及各超声心动图指标差异无统计学意义（P＞0.05）.阿托伐他汀组中患者缺血性心衰亚组与非缺血性心衰亚组相比各指标差异无统计学意义.结论 阿托伐他汀可显著改善慢性心力衰竭患者心功能,可作为一种治疗慢性心力衰竭的辅助治疗策略。Objective To analyze plasma N-terminal prohormone brain natriuretic peptide （NT-proBNP） levels and cardiac function in patients with chronic heart failure （HF） of various etiologies, and who were treated with or without statins. Methods The study cohort consisted of 139 consecutive male patients receiving Atorvas- tatin（n=44 ）, Simvastatin （ n=29 ）, Pravastatin（ n= 19 ）, or no statin（n=47 ）. The NT-proBNP levels were measured using electrol immunoassay. Left ventricular end-diastolic diameter （LVEI）D）, fractional shortening （FS）, and ejection fraction （EF） were determined by echocardiography. Results Patients receiving Atorvastatin presented with reduced NT-proBNP levels [ （1552±3416）pg/ml vs （3771±6763）pg/ml, P〈0.01 ], and improved values of LVEDD[（65.2±8.9）mm vs （70.7±10.9）mm, P〈0.05] and EF [（33.2±12.6）% vs （28.2±9.6）%, P〈 0.05 ]. By contrast, plasma NT-proBNP and cardiac parameters in patients treated with statins other than Atorvastatin did not significantly differ from control. Atorvastatin treatment was equally effective in patients with ischemic and nonischemic HF. Conclusion Atorvastatin treatment is associated with improved cardiac function in HF, and may represent an additional option for patients with this disease.

关 键 词：N末端B型利钠肽原 慢性心力衰竭 阿托伐他汀 

分 类 号：R541.6[医药卫生—心血管疾病]