母体乙肝病毒标志物阳性与新生儿听力复筛结果相关性分析  

Correlation Analysis between Mothers with Hepatitis B and 42-days Newborn Hearing Screening

作　　者：鲍诗平[1] 张帆[1] 刘勇刚[1] 张伟[1] 张淼[1] 

机构地区：[1]首都医科大学附属北京佑安医院耳鼻咽喉头颈外科,北京100069

出　　处：《中国听力语言康复科学杂志》2014年第6期429-432,共4页Chinese Scientific Journal of Hearing and Speech Rehabilitation

基　　金：佑安肝病艾滋病基金（BJYAH-2011-007）

摘　　要：目的：探讨初筛未通过的新生儿42天听力复筛结果是否受母体乙肝病毒感染的影响。方法采用畸变产物耳声发射（DPOAE）测试，对初筛未通过且乙肝病毒标志物阳性产妇所产新生儿进行42天听力复筛。结果本研究331例新生儿中，听力复筛通过289例，复筛通过率87.31%。母血HBeAg阳性组的脐血HBsAg与HBeAg阳性新生儿显著高于母血HBeAg阴性组（P＜0.01）；同时母血HBeAg阳性组以及母血HBV DNA阳性组的复筛通过率低于阴性组（P＜0.05）。结论妊娠母血HBeAg阳性和母血HBV DNA阳性与新生儿宫内感染以及听力复筛不通过存在一定联系，今后工作中应密切关注和定期随访。Objective To explore whether the infective factor will affect the results of 42-days hearing screening in newborns whose mother with hepatitis B. Methods All theinfants born to mothers with hepatitis B performed with 42-days hearing screening in distortion product otoacoustic emissions（DPOAE）. Results Among331 cases, 289 cases passed 42-days hearing screening.The rate was 87.31%. In the groups with mother pregnancywithHBeAg（＋）,the rate of neonates with HBsAg（＋） and HBeAg（＋） wassignificantly higher than that of neonates whose mother pregnancy with HBeAg（-）（P〈0.01）. Meantime, in the groups with mother pregnancywithHBeAg（＋） or HBV DNA（＋）, the rate of passing42-days hearing screening wassignificantly lower than the rate in the groups of mother pregnancy with HBeAg（-） or HBV DNA（-）（P〈0.05）. Conclusion There was interactive relationships between mother pregnancy with HBeAg（＋） or HBV DNA（＋） and neonates intrauterine infection as well as failed in hearing screening in our research. In the future research, we should pay more attention and follow-up regularly.

关 键 词：乙肝病毒标志物 新生儿听力复筛 畸变产物耳声发射 

分 类 号：R521[医药卫生—内科学]