血小板与白细胞比值在预测慢性乙型肝炎肝纤维化中的临床意义  

The clinical significance of platelet and white blood cell ratio in predicting liver fibrosis in chronic hepatitis B

作　　者：郭向东[1] 郭伟[2] 阿曼古[1] 曹丽[1] 闫鹏[1] 张荣[1] 

机构地区：[1]新疆生产建设兵团第一师医院感染性疾病科,新疆阿克苏843000 [2]新疆生产建设兵团第一师医院检验科,新疆阿克苏843000

出　　处：《中国现代医生》2014年第33期149-151,共3页China Modern Doctor

基　　金：新疆生产建设兵团第一师科研课题(2013YL04)

摘　　要：目的评价血小板(PLT)与白细胞(WBC)比值(PWRI)在预测慢性乙型肝炎(CHB)肝纤维化中的临床意义。方法对250例乙肝病毒(HBV)感染者进行肝组织学检查,同时检测血小板与白细胞,计算PWRI。比较肝纤维化者与携带者之间的PWRI。通过PWRI的受试者工作特征(ROC)曲线下面积,分析其预测肝纤维化的准确率。结果PWRI在肝纤维化患者明显低于携带者(P<0.01)。其预测HBV感染者出现肝纤维化的ROC曲线下面积为0.903。PWRI<30为肝纤维化的最优截断点,其阳性预测值为87.83%、阴性预测值为80.39%。结论PWRI可作为预测HBV感染者发生肝纤维化的指标之一。Objective To evaluate the clinical significance of platelet（PLT） and white blood cell（WBC） ratio（PWRI）in predicting chronic hepatitis B（CHB） liver fibrosis. Methods A total of 250 cases who infected hepatitis B virus（HBV）underwent liver histology examination, platelets and white blood cells detection then calculated PWRI. The PWRI between liver fibrosis and HBV carriers were compared. Through the area of ROC curve of PWRI for the studied cases,analyze its predictive accuracy rate of liver fibrosis. Results PWRI significantly lower in patients with liver fibrosis than HBV carriers（P〈0.01）. Area under the ROC curve pre dicting HBV-infected would occur liver fibrosis was 0.903.PWRI 30 was the optimal cutoff point of liver fibrosis, the positive predictive value of 87.83%, negative predictive value of 80.39%. Conclusion PWRI can be used as predictive indicators of HBV infected cases occur liver fibrosis.

关 键 词：乙肝病毒感染者 肝纤维化 乙肝病毒携带者 血小板计数 血小板与白细胞比值 

分 类 号：R512.6[医药卫生—内科学]