夜来香多糖镇静催眠作用的研究  

Study on the sedative-hypnotic effect of Cestrum nocturum L. polysaccharide

作　　者：谭晓彬[1] 程庚金生 罗江洪[2] 张新红[1] 曾雪亮[1] 曾靖[2] 

机构地区：[1]赣南医学院第一附属医院检验科,江西赣州341000 [2]赣南医学院药理教研室,江西赣州341000

出　　处：《中国当代医药》2014年第33期112-114,共3页China Modern Medicine

基　　金：江西省卫生厅科技计划项目(20123180)

摘　　要：目的探讨夜来香多糖对小鼠镇静催眠作用的影响。方法将小鼠随机分为生理盐水组(戊巴比妥钠组)、1.0 mg/kg夜来香多糖组、2.0 mg/kg夜来香多糖组、4.0 mg/kg夜来香多糖组。观察夜来香多糖对小鼠自发活动的影响、对阈上剂量戊巴比妥钠小鼠睡眠时间的影响、对阈下剂量戊巴比妥钠小鼠睡眠时间的影响。结果与生理盐水组比较,2.0、4.0 mg/kg的夜来香多糖能显著抑制小鼠自发活动(P<0.05,P<0.01);与戊巴比妥钠组比较,2.0、4.0 mg/kg的夜来香多糖能显著加速阈上剂量戊巴比妥钠的入睡时间和延长戊巴比妥钠的睡眠时间(P<0.05,P<0.01);与戊巴比妥钠组比较,1.0、2.0、4.0 mg/kg的夜来香多糖能显著加速阈下剂量戊巴比妥钠的入睡时间和延长戊巴比妥钠的睡眠时间(P<0.05,P<0.01,P<0.01)。结论夜来香多糖具有明显的镇静催眠作用。Objective To explore the sedative-hypnotic effect of Cestrum nocturum L. polysaccharide on mice model.Methods The mice were randomly divided into four groups including physiological saline（sodium pentobarbital） control group,1.0,2.0 and 4.0 mg/kg Cestrum nocturum L. polysaccharide groups.The influence of Cestrum nocturum L.polysaccharide on mice,the influence of sleeping time in mice on the above threshold dose of pentobarbital sodium,the influence of sleeping time in mice of subthreshold dose of pentobarbital sodium was observed respectively. Results Compared with the physiological saline group,2.0,4.0 mg/kg of Cestrum nocturum L. polysaccharide could significantly inhibit the spontaneous activity of mice（P〈0.05,P〈0.01）.Compared with the sodium pentobarbital group,2.0 mg/kg,4.0 mg/kg of Cestrum nocturum L. polysaccharide could significantly accelerate sleeping time on the above threshold dose of pentobarbital sodium and prolong sodium sleep time（P 〈0.05,P 〈0.01）.Compared with the sodium pentobarbital group,1.0,2.0,4.0 mg/kg of Cestrum nocturum L. polysaccharide could significantly accelerate the sleep time of subthreshold dose of pentobarbital sodium and prolong the sleep time（P〈0.05,P〈0.01,P〈0.01）. Conclusion Cestrum nocturum L.polysaccharide has obviously sedative-hypnotic effect.

关 键 词：夜来香 多糖 镇静 催眠 

分 类 号：R961.1[医药卫生—药理学]