昆虫包涵体衍生型病毒经口感染相关蛋白的研究进展  

Research Progress of Proteins Associated with Per os Infectivity of the Occlusion-derived Virus

作　　者：相兴伟 周宇芳 

机构地区：[1]浙江省海洋开发研究院,舟山316000

出　　处：《生物技术通报》2014年第11期40-47,共8页Biotechnology Bulletin

基　　金：国家科技支撑项目(2012BAD29B06);浙江省自然科学基金项目(LQ14C170001)

摘　　要：了解昆虫杆状病毒包涵体衍生型病毒(Occlusion-derived virus,ODV)的经口感染相关蛋白对揭示杆状病毒建立原发感染的机制、明确昆虫的先天免疫系统,以及研究控制昆虫新策略等方面具有重要意义。目前已鉴定的经口感染因子(Per osinfectivity factors,PIF)包括P74、PIF1、PIF2、PIF3、PIF4、PIF5(ODV-E56)和PIF6。此外,与ODV病毒粒子经口感染有关的蛋白有ODV-E66、VP91、Ac108、ORF 145和ORF 150。综述近年来关于上述经口感染相关蛋白的结构和功能等研究成果,分析了这些蛋白的分子生物学特征。The study of baculovirus proteins associated withper os infectivity is of great importance not only for viral biology but also for the fact that these proteins expose vulnerabilities in the insect immune system and this knowledge is also fundamental for the development of new strategies for insect control. Recent researches show that the proteins associated withper os infectivity of the occlusion-derived virus（ODV） include P74, PIF1, PIF2, PIF3, PIF4, PIF5（ODV-E56）, PIF6, ODV-E66, VP91, Ac108, ORF 145 and ORF 150. This paper reviewed recent research achievements about the structure and function of the proteins and analyzed the molecular biology characteristics of these proteins.

关 键 词：杆状病毒 包涵体衍生型病毒 经口感染 分子特征 

分 类 号：Q939.4[生物学—微生物学]