MicroRNAs在棕色脂肪细胞分化过程中的作用  

Function of MicroRNAs During the Differentiation Process of Brown Adipocytes

作　　者：郝美林 黄英[1] 黄丽梅[1] 杨明华[1] 李琦华[1] 贾俊静[1] 赵素梅[1] 

机构地区：[1]云南农业大学云南省动物营养与饲料重点实验室,昆明650201

出　　处：《生物技术通报》2014年第11期73-78,共6页Biotechnology Bulletin

基　　金：国家高技术研究发展计划项目(2011AA100305);国家自然科学基金项目(30660132;31060331;31260592);云南省自然科学基金项目(2009CD056)

摘　　要：MicroRNA(miRNA)是一种非编码的小分子RNA,负性调控转录后基因表达。miRNA在个体时序性发育、细胞增殖分化和凋亡、器官发育、脂肪代谢等许多生物发育过程中起着重要作用。近年来对miRNA的研究证实,miRNA直接或间接影响棕色脂肪组织发育过程中重要转录因子的表达。综述了miRNA调节棕色脂肪细胞分化的最新研究进展。MicroRNAs（miRNAs）are small, non-coding regulatory RNAs, which negatively regulate post-transcriptionally gene expression. miRNA plays the role in many biological functions including controlling the developmental timing, regulation of cell differentiation and apoptosis, organ development, fat metabolism. Recent studies indicated that the expression levels of transcriptional factors related genes which were important for the development of brown adipocyte tissue was affected by miRNAs directly or indirectly. This article reviewed the recent progress on the function of miRNA during the differentiation process of brown adipocytes.

关 键 词：棕色脂肪细胞 米色脂肪细胞 

分 类 号：Q254[生物学—细胞生物学]