电针对慢性情绪应激焦虑大鼠中枢儿茶酚胺类神经递质的调节作用研究  

Regulation Effects of Electro-acupuncture on Catecholamine Neurotransmitters in Centrum of Chronic Emotional Stress-induced Anxiety

作　　者：魏大能[1] 周奇志[1] 蔡定均[1] 赵纪岚[1] 王薇[1] 徐海洋[1] 

机构地区：[1]成都中医药大学针灸推拿学院,成都610075

出　　处：《中国中医基础医学杂志》2014年第11期1542-1543,1546,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金资助项目-针刺"宁心安神"治疗焦虑障碍的利钠肽-HPA轴调控机制研究(81173322)

摘　　要：目的:研究电针对慢性情绪应激(Chronic emotional stress,CES)焦虑模型大鼠中枢儿茶酚胺类神经递质含量的影响,丰富电针抗焦虑中枢效应机制。方法:采用不可预知的慢性情绪应激法,连续刺激大鼠21 d并建立CES焦虑大鼠模型。造模同时每日电针大鼠"百会"、"三阴交"穴,直至造模结束。运用荧光分光光度法分别测定大鼠下丘脑、杏仁核区儿茶酚胺类神经递质去甲肾上腺素(norepinephrine,NE)和多巴胺(dopamine,DA)的含量。结果:与空白组比较,模型组大鼠下丘脑、杏仁核NE和DA的含量均明显升高(P<0.05);与模型组比较,除下丘脑DA外,电针组两脑区儿茶酚胺类神经递质含量均下降(P<0.05或P<0.01)。结论:电针抗焦虑效应可能与降低中枢儿茶酚胺类神经递质有关。Objective： To research the effects of electro-acupuncture（EA）on the catecholaminergic neurotransmitter in centrum of chronic emotional stress-induced anxiety in rats. Methods： Chronic emotional stress anxiety model was established by using chronic unpredictable emotional stress methods for 21 days. EA was applied to Baihui（GV20） and Sanyinjiao（SP6） and lasted for 21 days. The contents of NE and DA in the hypothalamus and the amygdala nucleus were measured by fluorospectrophotometry. Results： Compared with control group,the contents of NE and DA were obviously increased in the model group（P 〈0. 05） ;The contents of NE and DA were obviously decreased in the EA group compared with the model group except the DA in hypothalamus （P 〈 0. 05 or P 〈 0. 01 ）. Conclusion： Anti-anxiety effect of EA is possibly related to lower the central catecholamine neurotransmitters.

关 键 词：电针 慢性情绪应激 焦虑障碍 NE DA 

分 类 号：R245.97[医药卫生—针灸推拿学]