复方硒口服液的研制与质量控制  

Preparation and quality control of Compound Polysaccharide Selenate Solution

作　　者：毛耀南 王和林[1] 魏润新[1] 钱南萍 

机构地区：[1]江苏省泰州市人民医院,泰州225300

出　　处：《西北药学杂志》2014年第6期586-589,共4页Northwest Pharmaceutical Journal

摘　　要：目的：研制复方硒口服液的处方和制备工艺，建立质量标准。方法配制复方硒口服液，采用氢化物原子荧光法测定复方硒口服液的含硒量。结果复方硒口服液质量稳定，硒质量浓度在10．0～120．0μg·L^-1范围内线性关系良好，（r ＝0．9997， n＝5），平均回收率为100．5％，RSD 为1．42％（n＝5）。结论复方硒口服液组方合理，制备工艺简便可行，含量测定方法特异性强，质量可控。Objective To prepare Compound Polysaccharide Selenate Solution ,and establish its quality control method .Methods The con-tent of selenium in Compound Polysaccharide Selenate Solution was measured by fluorescence spectrophotometry .Results The quality of Compound Polysaccharide Selenate Solution was stable .Selenium concentration in the range of 10 .0-120 .0 μg ？ L - 1 showed good linerity （ r= 0 .999 7 ,n= 5） .The average recovery rate was 100 .5% ,RSD = 1 .4% （n= 5） .Conclusion Compound Polysaccharide Selenate Solution was designed reasonably .This method is simple and feasible .The method of content determinination is accu-rate ,and can be used for the quality control .

关 键 词：复方硒口服液 质量控制 氢化物原子荧光法 

分 类 号：R94[医药卫生—药剂学]