钩吻素子对大鼠焦虑行为的影响  

Effects of koumine on the behavior of rat in elevated plus maze

作　　者：黄慧慧[1] 刘铭[1] 陈超杰[1] 俞昌喜[1] 

机构地区：[1]福建医科大学药学院,福州350004

出　　处：《西北药学杂志》2014年第6期593-595,共3页Northwest Pharmaceutical Journal

基　　金：国家自然科学基金青年科学基金项目(编号:81302756);教育部高等学校博士学科点专项科研基金(编号:20133518110004)

摘　　要：目的进一步明确钩吻素子是否具有抗焦虑作用。方法以大鼠高架十字迷宫实验为动物模型,评价钩吻素子单次皮下注射给药和连续皮下注射给药的抗焦虑活性及特点。结果钩吻素子能显著增加大鼠进入高架十字迷宫开臂次数和在开臂的停留时间百分率(P<0.05,P<0.01);钩吻素子在实验剂量下对大鼠自主运动活性无影响(P>0.05)。结论钩吻素子可能具有抗焦虑作用。Objective To observe the anxiolytic effects of koumine .Methods Effects of acute subcutaneous administration and con-secutively subcutaneous administration of koumine on antianxiety activity were observed and evaluated by using the rat elevated plus maze model .Results Koumine exhibited significant increases in the percentage of open arm entries and the percent time spent in open arms（P〈 0 .05 ,P〈 0 .01） .Moreover ,no effect on the locomotor activity of rats was accompanied in experimental doses（P〉 0 .05） .Conclusion Koumine may have anxiolytic effects .

关 键 词：钩吻素子 焦虑 高架十字迷宫 

分 类 号：R964[医药卫生—药理学]