布拉酵母菌与酪酸梭菌治疗婴幼儿轮状病毒性肠炎的疗效及安全性比较  

S. boulardii sachets and Clostridium butyricum treating rotavirus viral enteritis in infants: a comparison of efficacy and safety

作　　者：李忠 胡爱华 方国兴 胡国华 

机构地区：[1]金华市妇幼保健院,浙江金华321000

出　　处：《中国微生态学杂志》2014年第11期1311-1313,共3页Chinese Journal of Microecology

摘　　要：目的比较布拉酵母菌与酪酸梭菌治疗小儿轮状病毒性肠炎(Rotavirus viral enteritis,RVE)的疗效及安全性。方法将68例RVE患儿随机分为观察组和对照组。两组均予常规治疗(抗病毒、补液、纠正水电解质及酸碱平衡紊乱)。对照组予以酪酸梭菌,<1岁0.25 g/次,>1岁0.50 g/次,bid口服;观察组用布拉酵母菌,<1岁0.125 g/次,>1岁0.25 g/次,bid口服。5 d为一个疗程,观察两组患儿治疗后临床疗效、症状与体征消失时间及不良反应。结果观察组临床总有效率为94.29%,明显高于对照组的69.70%(χ2=7.06,P<0.01)。观察组症状与体征消失时间明显短于对照组(P<0.01)。治疗过程中对照组便秘3例,腹痛1例。观察组未见明显不良反应。结论布拉酵母菌治疗小儿RVE具有较好的临床疗效及安全性。Objective To compare the efficacy and safety of S. boulardii sachets and Clostridium butyricum in treatment of rotavirus viral enteritis（ RVE） in infants. Methods RVE infants were divided into treatment group and control group randomly. Both groups were treated with conventional treatment（ antiviral treatment,fluid in fusion,regulating water electrolyte）. The control group was additionally given Clostridium butyricum orally（ 0. 25 g for age〈 1 year,0. 50 g for age 〉1 years,bid）,while the treatment group was given S. boulardii sachets orally（ 0. 125 g for age〈 1 year,0. 25 g for age 〉1 years,bid）. The treatment course was 5 days. The clinical efficacy,time to disappearance of symptoms and sign,and side-effect were observed. Results The total efficacy rate of treatment group was 94. 29%,while the control group was 69. 70%（ χ^2= 7. 06,P〈0. 01）. The time to disappearance of symptoms and signs of treatment group was apparently shorter than that of control group（ P〈0. 01）.During the treatment,3 cases of constipation and 1 case of stomach pain occurred in the control group. No sideeffects happened in the treatment group. Conclusion S. boulardii sachets has a satisfactory clinical effect and safety for the treatment of infant RVE.

关 键 词：轮状病毒性肠炎 布拉酵母菌散 酪酸梭菌 小儿 

分 类 号：R723.11[医药卫生—儿科]