前列腺素E1对早期糖尿病肾病患者UAER和内皮细胞功能vWF水平的影响  

Prostaglandin El in treatment of patients with early diabetic nephropathy

作　　者：朱炜丹 陈丽华[3] 陈江华[1] 

机构地区：[1]浙江大学医学院附属第一医院肾脏病中心,杭州310003 [2]杭州市余杭区第三人民医院 [3]杭州市余杭区第三人民医院内三科

出　　处：《浙江医学》2014年第19期1638-1639,共2页Zhejiang Medical Journal

基　　金：卫生部行业科研专项项目资助(201002010)

摘　　要：目的探讨前列腺素E1对早期糖尿病肾病患者24h尿白蛋白排泄率(UAER)和内皮细胞功能血浆血管性血友病因子(vWF)水平的影响。方法选择60例早期糖尿病肾病患者,按照就诊顺序分为观察组和对照组,各30例。两组患者均给予相关的常规治疗,观察组在此基础上采用前列腺素E1 10μg+0.9%氯化钠注射液50 ml静脉推注,对照组予0.9%氯化钠注射液50ml静脉推注,治疗2周。检测两组患者治疗前后血浆vWF和UAER水平。结果治疗期间两组患者均未出现明显药物不良反应。两组患者治疗前后UAER和vWF水平的差异均有统计学意义(均P<0.01),但观察组治疗后UAER和vWF水平的改善程度更为明显(均P<0.01)。结论前列腺素E1能够改善早期糖尿病肾病患者血管内皮功能,提高治疗效果,值得临床考虑。Objective To evaluate the efficacy of prostaglandin E1 in treatment of patients with early diabetic nephropa-thy （DN）. Methods Sixty patients with early DN were divided into observation group and control group. On the bases of routine therapy, patients in observation group （n=30） received prostaglandin E1（10μg in 0.9%normal saline, intravenous drip）, patients in control group （n=30） received same volume of normal saline for 2 weeks. 24h urinary albumin excretion rate and endothelial function von Wil ebrand factor （vWF） levels were measured before and after treatment. Results There were no significant differ-ences in UAER and vWF levels between two groups before treatment. UAER and vWF levels in both group were improved sig-nificantly after treatment （al P〈0.01）, however, compared to control group these indexes were improved more markedly in ob-servation group （P〈0.01）. Conclusion Prostaglandin El can improve vascular endothelial function in patients with early DN with the reduction of UAER and vWF levels.

关 键 词：前列腺素E1 尿白蛋白排泄率 血浆血管性血友病因子 

分 类 号：R587.2[医药卫生—内分泌]