胎膜早破孕妇生殖道支原体和衣原体感染及支原体耐药性分析  

Themycoplasma and chlamydia infection and drug resistance of mycoplasma of pregnant women with premature rupture of membranes

作　　者：陈丰华[1] 洪海 

机构地区：[1]义乌市中心医院妇产科,浙江金华322000 [2]辉瑞(北京)国际医学研究院药物实验中心,北京102299

出　　处：《中国性科学》2014年第11期90-92,共3页Chinese Journal of Human Sexuality

摘　　要：目的：了解胎膜早破孕妇生殖道支原体和衣原体感染及耐药性，为临床孕妇支原体和衣原体筛查及治疗提供依据。方法：选取胎膜早破孕产妇368例，由妇产科医师取其宫颈口内2cm左右处宫颈分泌物进行uu和ct检测及药敏试验，观察检测及药敏试验结果。结果：368例胎膜早破患者中，病原体阳性率为78．26％（288／368），其中，Uu单一感染55．82％（205／368），Ct单一感染5．98％（22／368），Uu＋Mh感染4．08％（15／368），Uu＋Ct感染7．61％（28／368）、Uu＋Mh＋ct感染0．82％（3／368），Uu感染率为68.21％（251／368），ct感染率为14．40％（53／368）；药敏结果显示，uu对强力霉素和米诺环素耐药率为0，对交沙霉素耐药率为3．41％，对四环素耐药率为22．93％，对红霉素等大环内酯类耐药率均超过50％，对诺氟沙星等喹诺酮类耐药率为40％～50％左右；ct对强力霉素及米诺环素耐药率为4．55％，对四环素耐药率为22．73％，对交沙霉素耐药率为31．82％，对其他大环内酯类及喹诺酮类耐药率均超过50％；Uu＋Ct混合感染时，耐药性与uu和ct单一感染时类似，但耐药率均有所升高，尤其对米诺环素及强力霉素耐药率升高最为明显。结论：胎膜早破孕产妇生殖道中支原体的高检出率及Ct检出率提示其与胎膜旱破密切相关，临床治疗时可选择四环素类，可首选交沙霉素、米诺环素、强力霉素。Objectives： To understand the status of hemycoplasma and chlamydia infection and drug resist- ante of reproductive tract of pregnant women with premature rupture of membranes （PROM） , providing basis for clinical myeoplasma and chlamydia screening and treatment. Methods： 368 pregnant women with PROM were se- lected to conduct Uu and Ct detection and susceptibility testing, and the results were recorded. Results： The patho- gens positive rate of all 368 pregnant women was 78.26% （288/368）, including 55.82% （205/368） of Uu single infection, 5.98% （22/368） of Ct single infection, 4.08% （15/368） of Uu ＋ Mh infection, 7.61% （28/368） of Uu ＋ Ct infection, 0.82% （3/368） of Uu ＋ Mh ＋ Ct infection, 68.21% （251/368） of Uu infection and 14. 40% （53/368） of Ct infection; as the susceptibility results showed, the resistance of Uu against doxycycline and minocycline was 0, 3.41% for josamycin, 22.93 % for tetracycline, over 50% for erythromycin and other maeroli- de and about 40% -50% for norfloxacin quinolone; while the resistance rate of Ct was 4.55% for doxycycline and minocycline, 22.73% for tetracycline, 31.82% for josamyein, and over 50% for other macrolides and quinolones; in mixed infection of Uu ＋ Ct, the drug resistance was similar with increased resistance rate, especially for minocy- dine and doxyeycline. Conclusion： The high detection rate of mycoplasma and Ct suggest it is closely associated with PROM and tetracyclines especially josamycine, minocycline and doxycycline are preferred for clinical treat- ment.

关 键 词：胎膜早破 解脲支原体 沙眼衣原体 药敏试验 

分 类 号：R375[医药卫生—病原生物学]