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机构地区:[1]义乌市中心医院妇产科,浙江金华322000 [2]辉瑞(北京)国际医学研究院药物实验中心,北京102299
出 处:《中国性科学》2014年第11期90-92,共3页Chinese Journal of Human Sexuality
摘 要:目的:了解胎膜早破孕妇生殖道支原体和衣原体感染及耐药性,为临床孕妇支原体和衣原体筛查及治疗提供依据。方法:选取胎膜早破孕产妇368例,由妇产科医师取其宫颈口内2cm左右处宫颈分泌物进行uu和ct检测及药敏试验,观察检测及药敏试验结果。结果:368例胎膜早破患者中,病原体阳性率为78.26%(288/368),其中,Uu单一感染55.82%(205/368),Ct单一感染5.98%(22/368),Uu+Mh感染4.08%(15/368),Uu+Ct感染7.61%(28/368)、Uu+Mh+ct感染0.82%(3/368),Uu感染率为68.21%(251/368),ct感染率为14.40%(53/368);药敏结果显示,uu对强力霉素和米诺环素耐药率为0,对交沙霉素耐药率为3.41%,对四环素耐药率为22.93%,对红霉素等大环内酯类耐药率均超过50%,对诺氟沙星等喹诺酮类耐药率为40%~50%左右;ct对强力霉素及米诺环素耐药率为4.55%,对四环素耐药率为22.73%,对交沙霉素耐药率为31.82%,对其他大环内酯类及喹诺酮类耐药率均超过50%;Uu+Ct混合感染时,耐药性与uu和ct单一感染时类似,但耐药率均有所升高,尤其对米诺环素及强力霉素耐药率升高最为明显。结论:胎膜早破孕产妇生殖道中支原体的高检出率及Ct检出率提示其与胎膜旱破密切相关,临床治疗时可选择四环素类,可首选交沙霉素、米诺环素、强力霉素。Objectives: To understand the status of hemycoplasma and chlamydia infection and drug resist- ante of reproductive tract of pregnant women with premature rupture of membranes (PROM) , providing basis for clinical myeoplasma and chlamydia screening and treatment. Methods: 368 pregnant women with PROM were se- lected to conduct Uu and Ct detection and susceptibility testing, and the results were recorded. Results: The patho- gens positive rate of all 368 pregnant women was 78.26% (288/368), including 55.82% (205/368) of Uu single infection, 5.98% (22/368) of Ct single infection, 4.08% (15/368) of Uu + Mh infection, 7.61% (28/368) of Uu + Ct infection, 0.82% (3/368) of Uu + Mh + Ct infection, 68.21% (251/368) of Uu infection and 14. 40% (53/368) of Ct infection; as the susceptibility results showed, the resistance of Uu against doxycycline and minocycline was 0, 3.41% for josamycin, 22.93 % for tetracycline, over 50% for erythromycin and other maeroli- de and about 40% -50% for norfloxacin quinolone; while the resistance rate of Ct was 4.55% for doxycycline and minocycline, 22.73% for tetracycline, 31.82% for josamyein, and over 50% for other macrolides and quinolones; in mixed infection of Uu + Ct, the drug resistance was similar with increased resistance rate, especially for minocy- dine and doxyeycline. Conclusion: The high detection rate of mycoplasma and Ct suggest it is closely associated with PROM and tetracyclines especially josamycine, minocycline and doxycycline are preferred for clinical treat- ment.
分 类 号:R375[医药卫生—病原生物学]
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