肺表面活性物质对新生儿胎粪吸入综合征肺氧合功能的影响  

Influence of pulmonary surfactant on pulmonary oxygenation function of meconium aspiration syndrome

作　　者：高飞[1] 刁玉霞[2] 赵雪吉 

机构地区：[1]吉林市妇产医院,132011 [2]吉林市儿童医院 [3]吉林卫生学校

出　　处：《中国实用医药》2014年第32期15-16,共2页China Practical Medicine

摘　　要：目的研究探讨肺表面活性物质(PS)对新生儿胎粪吸入综合征(MAS)的肺氧合功能的影响。方法采用气管内滴入PS治疗10例MAS患儿,对用药前、用药后30 min、2 h及6 h血气指标,机械通气参数进行比较分析,判断肺氧合情况。结果 10例患儿血气指标及机械通气的参数用药前与用药30 min后比较差异有统计学意义(P<0.05),动脉血氧分压(Pa O2)由(42.81±4.68)mm Hg(1 mm Hg=0.133 k Pa)升高至(55.19±4.82)mm Hg,动脉与肺泡氧分压比值(a/APO2)由(0.11±0.06)升高至(0.20±0.05),动脉血氧分压与吸入氧浓度比值(Pa O2/Fi O2)由(67.04±18.00)mm Hg升高至(97.13±24.14)mm Hg,Fi O2由(0.66±0.10)降至(0.54±0.08),平均气道压(MAP)由(15.52±3.15)cm H2O(1 cm H2O=0.098 k Pa)降至(11.67±2.85)cm H2O。氧合指数(OI)由(22.16±2.12)降至(14.16±1.67),差异均具有统计学意义(P<0.05)。结论肺表面活性物质能有效地改善MAS患儿肺氧合功能。Objective To explore the influence of pulmonary surfactant （PS） on pulmonary oxygenation function of meconium aspiration syndrome （MAS）. Methods A total of 10 infants with MAS were treated by PS through intratracheal instillation. Comparisons were made on the blood gas, mechanical ventilation parameters, and ratio of arterial partial pressure of oxygen and oxygen concentration before and in 30 min, 2 h and 6 h after treatment medication, in order to analyze the condition of pulmonary oxygenation. Results The difference of blood gas and mechanical ventilation parameters in the 10 infants between the time before medication and 30 min after medication was statistically significant （P〈0.05）. Arterial partial pressure of oxygen （PaO2） increased from （42.81＆±4.68） mm Hg （1 mm Hg=0.133 kPa） to （55.19＆±4.82） mm Hg. Ratio of artery and alveolar partial pressure of oxygen （a/PaO2） increased from （0.11＆±0.06） to （0.20＆±0.05）. Ratio of arterial partial pressure of oxygen and oxygen concentration （PaO2/FiO2） increased from （67.04＆±18.00） mm Hg to （97.13＆±24.14） mm Hg. FiO2 decreased from （0.66＆±0.10） to （0.54＆±0.08）. Mean arterial pressure （MAP） decreased from （15.52＆±3.15） cm H2O （1 cm H2O=0.098 kPa） to （11.67＆±2.85） cm H2O. Oxygenation index （OI） decreased from （22.16＆±2.12） to （14.16＆±1.67）. The differences had statistical significance （P〈0.05）. Conclusion PS can efficiently improve the pulmonary oxygenation function of MAS infants.

关 键 词：肺表面活性物质 新生儿胎粪吸入综合征 肺氧合功能 

分 类 号：R722.1[医药卫生—儿科]