氟康唑预防早产儿侵袭性真菌感染的效果  

Preventive effect of Fluconazole prophylaxis on invasive fungous infections of premature infants

作　　者：刘郴州[1] 林丽丹[1] 温碧霞[1] 许小慧[1] 关浩锋[1] 黄碧茵[1] 郭青云[1] 

机构地区：[1]中山大学附属江门医院儿科重症监护病区,江门市中心医院529030

出　　处：《中华实用儿科临床杂志》2014年第22期1751-1753,共3页Chinese Journal of Applied Clinical Pediatrics

摘　　要：目的 探讨氟康唑预防早产儿侵袭性真菌感染的效果。方法 采用回顾性研究的方法，对2008年2月至2013年10月在江门市中心医院住院治疗且符合病例纳入标准的234例早产儿的临床资料进行分析，按照是否使用及口服应用还是静脉应用氟康唑预防早产儿侵袭性真菌感染将患儿分为3组：A 组为未使用氟康唑预防组，B组为口服应用氟康唑预防组［6 mg/（kg·次），隔天 1次］，C 组为静脉应用氟康唑预防组［3 mg/（kg·次），每3天1次］。比较 3组侵袭性真菌感染的发生率。结果 A 组 53例，B 组 115例，C 组66例，3组间性别比、出生胎龄、出生体质量、住院天数、静脉营养使用天数、经外周穿刺中心静脉导管置管天数、使用抗生素天数、使用有创机械通气天数比较差异均无统计学意义（P均 〉0.05）；其中 A 组、B组、C组侵袭性真菌感染的发生率分别为11.32%（6/53例）、6.96%（8/115例）、0；3组效果不全相同（χ2=7.078，P =0.029），其中A组与B组比较差异无统计学意义（χ2=0.905，P =0.342），C组优于A 组与 B组，差异有统计学意义（P =0.007，0.028）。结论 静脉应用氟康唑预防早产儿侵袭性真菌感染的效果较好，可以作为优先选择。Objective To explore the preventive effect of Fluconazole on invasive fungous infections in prema- ture infants. Methods Two hundred and thirty-four cases of preterm infants hospitalized in Jiangmen Central Hospital from Feb. 2008 to Oct. 2013 were analyzed by retrospective study. The subjects were divided into 3 groups based on whether Fluconazole was used and it was used orally or intravenously for the prevention of invasive fungous infections in premature infants. The Fluconazole prophylaxis was not given to group A, whereas oral Fluconazole prophylaxis [ 6 mg/（ kg · times）, every other day ] and intravenous Fluconazole prophylaxis [ 3 mg/ （ kg · times ）, once every 3 days ] were applied in group B and group C. The incidence of invasive fungous infections and the clinical effects of Fluconazole on the 3 groups were evaluated and compared. Results The number of cases analyzed in the study were 53, 115 and 66 cases in group A,group B and group C,respectively. There were no significant differences between the 3 groups in terms of gender, gestational age, birth weights, length of hospitalization, intravenous nutrition, and number of peripherally inserted central catheter, antibiotics and invasive mechanical ventilation use days （all P 〉 0.05 ）. The inci- dences of invasive fungal infections were 11.32% （6/53 cases） ,6.96% （8/115 cases） and 0 in group A,group B and group C, respectively. The prophylaxis effects between the 3 groups were significantly different （χ^2 = 7. 078, P = 0.029 ）. Group A and group B were not significantly different （χ^2 =0.905 ,P =0. 342） ,but group C was better than group A and group B, and the differences were significant （P = 0.007,0.028）. Conclusions Prevention of invasive fungous infections by intravenous Fluconazole has good curative effects,and which can be used as the first choice.

关 键 词：氟康唑 真菌 预防 婴儿 早产 

分 类 号：R722.6[医药卫生—儿科]