流感病毒HA受体结合位点抑制剂研究进展  

Progress on Inhibitor Agents of Influenza Virus HA Receptor Binding Site

作　　者：王文超[1] 王心竹 尹荣焕[1] 赵玉军[1] 刘娇[1] 王欣[1] 李化生[1] 田菁菁 

机构地区：[1]沈阳农业大学,辽宁沈阳110866 [2]辽宁农业职业技术学校,辽宁营口115009

出　　处：《动物医学进展》2014年第11期88-92,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31001088);辽宁省教育厅优秀人才支持项目(LJQ2013070)

摘　　要：目前临床所用控制流感病毒的药物和疫苗受到病毒耐药性、疫苗滞后性等诸多因素的限制,使能阻止病毒侵入宿主细胞的抑制剂成为当前研究的热点。唾液酸是流感病毒囊膜表面血凝素(HA)的受体,但研究表明唾液酸并不适合作为研制流感病毒侵入宿主细胞抑制剂的结构模型。研究发现流感病毒的HA受体结合位点必须外露才能与宿主细胞受体结合,因此HA受体结合位点可以被宿主免疫系统监视,成为抗体潜在的靶向契合位点。随后发现的HA受体结合位点抗体能与HA受体结合位点的保守氨基酸残基结合,能有效阻止流感病毒感染宿主。因此,可用HA受体结合位点抗体作为流感病毒感染抑制剂的模型,研制流感病毒抑制剂。论文就流感病毒HA的分子结构和功能,HA结合受体的机制,HA受体结合位点抗体以及该类抗体对流感病毒的抑制效果进行了阐述,以期对以HA受体结合位点抗体为模型研制流感病毒感染抑制剂提供帮助。The anti-flu drugs and flu vaccines were restricted at some time in clinic. So the influenza virus entry inhibitor agents has become the focus of current research. Sialic acid is the receptor of HA,but using sialic acid as viral entry blockers has not been successful, it indicates that sialic acid may not be an ideal scaffold for influenza virus entry inhibitor agents. The receptor binding site of HA must be exposed for binding to host sialic acid receptors, so that the system, as the potential target binding sites for receptor binding site can be monitored by the host immune antibodies. Some antibodies can bind the highly conserved amino acids on the receptor binding site of HA, that inhibits virus infection to hosts. So the antibodies tar- geting binding receptor site of HA may be the new idea for human combat influenza virus. This paper re- viewed the molecular structure and function of the influenza virus HA, mechanism of HA binding the re- ceptors, described the inhibition effect of the antibody to influenza virus entry, in order to supply help for preparation of antibodies inhibiting HA receptor binding site and research influenza virus entry inhibitor.

关 键 词：流感病毒 血凝素 受体结合位点 抑制剂 

分 类 号：S852.659.5[农业科学—基础兽医学]