赣州市人群血清同型半胱氨酸的水平和分布分析  

The blood homocysteine level and distribution analysis of Ganzhou city people

作　　者：江丽霞[1] 施少华[2] 钟星明[3] 阳贻红[4] 胡蓉[1] 席徐翔[1] 

机构地区：[1]赣南医学院第一附属医院检验科,江西赣州341000 [2]赣南医学院第一附属医院信息科,江西赣州341000 [3]赣南医学院第一附属医院药剂科,江西赣州341000 [4]赣南医学院第一附属医院心血管内科,江西赣州341000

出　　处：《重庆医学》2014年第31期4197-4199,4202,共4页Chongqing medicine

基　　金：江西省卫生厅课题(20133093)

摘　　要：目的：分析赣州市人群同型半胱氨酸（Hcy）水平和分布情况，为尽早对高同型半胱氨酸血症（HHcy）的群体进行干预、为预防心脑血管疾病提供理论依据。方法对2012年该院6419例25-74岁成人体检者采用酶法测定血清Hcy水平，采用SPSS17．0软件分别对HHcy的检出率及Hcy水平在不同年龄和性别中的分布进行分析。结果6419例体检者中HHcy的总检出率为39．11％，其中男性为47．30％，女性为22．49％，二者比较差异有统计学意义（χ2＝424．28，P＜0．05）；各年龄段内HHcy的检出率男性均高于女性，两两比较差异有统计学意义（P＜0．05）。随着年龄增加，男性和女性Hcy水平升高的检出率都呈上升趋势。同时，Hcy水平男性25-34岁组和35-44岁组、45-54岁组和55-64岁组比较，差异无统计学意义（P＞0．05），其余男性各年龄组之间、女性不同年龄组之间及同一年龄组内不同性别之间Hcy水平两两比较，差异均有统计学意义（P＜0．05）。结论赣州市人群HHcy的检出率及血Hcy水平分布存在地区特点，可能与该地区主要为客家人群及地区因素有关，HHcy的检出率比例较高，应尽早进行干预，以降低心脑血管疾病的风险。Objective We analysed the homocysteine level and distribution of ganzhou city crowd ,learned about its elevatory sit‐uation ,and provided theory basis for the intervention of high homocysteine level crowd and the prevention of heart and head blood vessel disease .Methods We detected the blood homocysteine level of 6419 adults who had physical examination in our hospital dur‐ing 2012 by enzymatic methods ,and analyzed the diagnose rate of HHcy and the distributions of Hcy in different age and gender . Results The total detection rate of high homocysteine level in 6419 adults was 39 .11% ,among which 47 .30% in male and 22 .49% in female ,the comparison was statistically significant （χ2 = 424 .28 ,P〈 0 .05） ;the detection rate of male was higher than female .In different ages ,the detection rates were statistically significant comparatively （P〈 0 .05） .The detection rate of homocys‐teine level in both gender rises with age .At the same time ,homocysteine levels in males of 25 - 34 years old age group and 35 - 44 years old age group ,45 - 54 years old age group and 55 - 64 yeas old age group were not statistically significant ;while there were statistical differences of Hcy level in the rest age groups of male ,different age groups of female and same age different gender groups （P〈 0 .05） .Conclusion The HHcy detection rate and the blood Hcy distribution of Ganzhou city crowd has its regional characteristics compared with other regions ,and it may be associated with the main population distribution of hakka people and oth‐er geological factors .The detection rate of HHcy was relatively high ,and it′s advisable to take early prevention to lower the risk of heart and head blood vessel disease .

关 键 词：赣州市 同型半胱氨酸 分布 

分 类 号：R589[医药卫生—内分泌]