降钙素原及C反应蛋白在高龄慢性阻塞性肺疾病急性加重期患者中的诊断价值  

The diagnostic value of procalcitonin and CRP in the acute exacerbation period of chronic obstructive pulmonary disease in elderly patients

作　　者：杨海燕[1] 付朝晖[1] 王喜春[1] 陈永[1] 

机构地区：[1]重庆市第三人民医院老年科,400014

出　　处：《重庆医学》2014年第32期4314-4315,4319,共3页Chongqing medicine

基　　金：重庆市卫生局科研基金资助项目(2013-2-090)

摘　　要：目的探讨降钙素原(PCT)及C反应蛋白(CRP)在高龄慢性阻塞性肺疾病急性加重期(AECOPD)患者中的诊断价值。方法收集本院大于或等于75岁AECOPD住院患者,入院后使用抗菌药物前检测其血清PCT及CRP值,分析两者敏感性及相关性。结果本研究共入选128例患者,CRP>10 mg/L敏感性为92.19%,PCT敏感性分别为(PCT>0.05ng/mL,43.75%,PCT>0.25ng/mL,28.13%);根据PCT值将患者分成3组,PCT<0.05ng/mL组CRP均值为42.86 mg/L,0.05ng/mL<PCT<0.25ng/mL组CRP均值为67.18mg/L,及PCT≥0.25ng/mL组CRP均值为88.07mg/L,3组比较差异有统计学意义(P<0.05)。结论高龄AECOPD患者PCT敏感性低,不能单独作为诊断细菌感染的指标;PCT越高的患者,其CRP也越高,两者早期联合检测有利于高龄AECOPD准确的诊断。Objective To discuss the diagnostic value of procalcitonin and C reactive protein in the acute exacerbation period of chronic obstructive pulmonary disease in elderly patients.Methods Patients ages 75 or more with AECOPD were selected,and the PCT and CRP in blood serum were detected before treated with antibiotics,then their sensibility and dependability were analyzed.Results Patients were concluded,the sensibility for CRP〉10mg/L was 92.19%,for PCT〉0.05ng/mL was 43.75%,for PCT〉0.25ng/mL was 28.13%.The three groups had statistics difference.Patients were divided into three groups according to PCT level,CRP had significant difference in the three groups（P〈0.05）：the mean value of CRP in PCT〈0.05ng/mL group was 42.86mg/L,the mean value of CRP in 0.05ng/mL〈PCT〈0.25ng/mL group was 67.18mg/L,and that of PCT≥0.25ng/mL group was 88.07mg/L.Conclusion Low sensibility of PCT was found in elderly patients with AECOPD,and PCT can not be regarded index of bacterial infection lonely.While the higher PCT patients,the CRP is also higher,the two index had the consistency.Therefore,the combined detection is more conducive to the early diagnosis of elderly AECOPD more accurate.

关 键 词：C反应蛋白质 肺疾病 慢性阻塞性 降钙素原 

分 类 号：R563.9[医药卫生—呼吸系统]