氧疗对移居3700m高原缺氧损伤预防作用的现场研究  

Field study of prevention of oxygen therapy from hypoxic injury in migrators at 3700 m high altitude above sea level

作　　者：崔建华 崔宇[2] 张俊才 高亮 张一新 王福领 高钰琪[2] 张钢[2] 黄缄[2] 

机构地区：[1]解放军18医院全军高山病防治研究中心,新疆叶城844900 [2]第三军医大学高原军事医学系

出　　处：《西南国防医药》2014年第11期1234-1237,共4页Medical Journal of National Defending Forces in Southwest China

基　　金：军队重大专项(13KJZ01);高原医学教育部重点实验室资助项目(2011JSGY05)

摘　　要：目的探讨氧疗对移居海拔3700 m高原人体缺氧损伤的预防作用。方法对海拔3700 m居住1年以上的120名男性青年随机分为A组(吸氧30 min/d,n=40)、B组(吸氧1 h/d,n=40)、C组(不吸氧,n=40),吸氧流量为2 L/min,连续吸氧30 d。检测吸氧前、吸氧15 d、30 d和停氧15 d慢性高原病(CMS)症状评分、睡眠质量评分、血红蛋白(Hb)浓度、HR、血压、呼吸频率、Sa O2和1000 m跑成绩。结果 B组吸氧15 d和30 d时与吸氧前比较,睡眠质量评分降低(P<0.05 or P<0.01)。A组与B组比较,吸氧15 d和30 d时的CMS症状评分、睡眠质量评分均降低(P<0.05或P<0.01);A组、B组吸氧30 d时和与吸氧前比较,Sa O2均升高(P<0.01)。A组、B组与C组比较,吸氧15 d、30 d及停氧15 d时,CMS症状评分降低、Hb浓度降低、Sa O2升高(P<0.05或P<0.01)。结论长期低浓度氧疗,可预防慢性高原病,改善高原睡氧眠质量,稳定或减轻Hb浓度增加。每天吸氧1 h要优于30 min。停止吸氧15 d后,生理指标恢复到吸氧前的水平。Objective To explore the prevention of oxygen therapy from hypoxic injury in migrators at 3700 m high altitude. Methods Total 120 young males who had lived in 3700 m high altitude above sea level for more than one year were selected and divided randomly into group A （inhaling oxygen for 30 min per day, n = 40 ）, group B （inhaling oxygen for one hour per day, n = 40 ）, and group C （ no oxygen inhalation, n = 40 ）. The oxygen flow rate was two liters per minute and the inhaling time was 30 consecutive days. Chronic mountain sickness （ CMS ） symptom scores, sleep quality score, hemoglobin （ Hb ） concentration, HR, blood pressure, respiratory rate, SaO2 and performance in 1000 m run were examined and evaluated before the oxygen inhalation, after 15 day and 30 day oxygen inhalation,and after oxygen inhalation had been stopped for 15 days,respectively. Results The sleep quality score of the subjects in group B after 15 day and 30 day oxygen inhalations was lower than that before the oxygen inhalation （ P 〈 0.05 or P 〈 0. 01 ）. The CMS symptom score and sleep quality score of the subjects in group A after 15 day and 30 day oxygen inhalations were lower than that in group B（P 〈0.05 or P 〈0.01 ） ;SaO2 of the subjects in both group A and B increased after 30 day oxygen inhalation in comparison with that before the oxygen inhalation（ P 〈 0. 01 ）. Besides, in comparison with group C, the CMS symptom score and Hb concentration of both group A and B decreased but SaO2 increased after 15 day and 30 day oxygen inhalations and after oxygen inhalation had been stopped for 15 days （ P 〈 0. 05 or P 〈 0.01 ）. Conclusion Long-term low-concentration oxygen therapy can prevent chronic mountain sickness,improve sleep quality, stabilize or reduce the increase of Hb concentration. The effect of oxygen inhalation for one hour every day will be better than that for 30 minutes. After oxygen inhalation is stopped for 15 days, the physiological indexes will recover to the level before the oxygen

关 键 词：高原 氧疗 CMS 睡眠质量 SAO2 

分 类 号：R594.3[医药卫生—内科学]