卡介菌多糖核酸联合他克莫司、复方甘草酸苷治疗特应性皮炎的疗效观察  

Clinical Observation on Therapeutic Effects of BCG-PSN Combined with Tacrolimus Ointment,Compound Glycyrrhizin for the Treatment of Patients with Atopic Dermatitis

作　　者：谭彦[1] 

机构地区：[1]湖南省汉寿县人民医院皮肤科,415900

出　　处：《医学理论与实践》2014年第21期2819-2821,共3页The Journal of Medical Theory and Practice

摘　　要：目的：观察卡介菌多糖核酸（BCG-PSN）联合0．03％他克莫司软膏、复方甘草酸苷片联合治疗特应性皮炎（AD）的疗效。方法：入选104例2～12岁的AD患者，随机分为两组：对照组（51例）和观察组（53例），给予为期4周的疗程，两组均给予常规的一般治疗，对照组在此基础上给予氯雷他定片及1．2％维生素B6软膏局部外用；观察组给予BCG-PSN肌肉注射，0．03％他克莫司局部外用，复方甘草酸苷片口服，两组治疗前、后采用SCORAD计分及外周血嗜酸性粒细胞（E）计数，进行疗效判定和总有效率比较，并作统计学分析和处理。结果：治疗前，两组SCORAD计分和E计数水平无明显统计学差异（P值均＞0．05）。治疗后，两组SCORAD计分及E计数水平均有明显下降（P值均＜0.05）。SCORAD计分：对照组为28．12±2．74，观察组为14．25±2．12；E计数水平分别为277．85±59．53，224．75±48．52，观察组均优于对照组（ P值均＜0．05）。总有效率：观察组为92．5％，对照组为76．5％。治疗组显著优于对照组（P＜0．05），两组治疗中不良反应发生率很低，无明显差异，不影响治疗，半年后随访未发现复发病例。结论：两组患者耐受性好，无严重不良反应，观察组疗效肯定，安全性好，优于对照组，值得临床推荐和进一步研究。Objective：To observe the efficacy of BCG-PSN combined with tacrolimus ointment, compound glycyrrhizin for the treatment of patients with Atopic Dermatitis （AD）. Methods：104 cases with AD were randomly divided into control group （51 cases） and observation group （53 cases）. Both groups patients with AD were given treated by general therapy for 4 weeks. On the basis of routine therapy. the control group was given orally administered Loratadine tablets and 1. 2% vitamin B6 ointment local external use;the observation group was given BCG-PSN i. m, 0. 03% Tacrolimus ointment local external use and the glycyrrhizin p. o. the treatment course was 4 weeks for both groups. The severity stroke patients with AD was evaluated according to SCORAD scoring system and levels of peripheral blood eosinophil （E） between the two groups were detected and calculated for before and after of treatment. And its were curative effect judgment and total effective tate in two group, and than compared and statistically analysed. Results：Before treatment, there were no statistics significant between the two groups on SCORAD value and levels of peripheral blood eosinophil （P〉0. 05）;after treatment, the SCORAD value and levels of E in the two groups markedly decreased ：the control group SCORAD value was 28. 12 ＆#177; 2. 74, level of E was 277. 85 ＆#177; 59. 53;the observation group was 14. 25 ＆#177; 2. 12, 224.75 ＆#177; 48. 52, the observation group was all better than the control group （P〈0. 05）;the total effective rate was 92.5% VS 76. 5% respectively, the observation group was better than the control group （P〈0. 05）. The incidence of adverse reaction was lower, which its no obvious difference between the two group, its were not influence therapy, no discover a relapse case after 6 months at will visit. Conclusion：After treatment, the two groups with AD have good tol-erability and effectiveness. The observation group is curative effect affirmation in treating patients with AD. It’s better tha

关 键 词：特应性皮炎 卡介多菌糖核酸 他克莫司 复方甘草酸苷 治疗 

分 类 号：R751[医药卫生—皮肤病学与性病学]