马齿苋总黄酮微乳的制备及经皮渗透研究  

Preparation and in Vitro Transdermal Delivery of Portulaca Total Flavone Microemulsion

作　　者：张丹霞[1] 赖东梅[1] 江美芳[1] 谢峥伟[1] 黄华轼[1] 

机构地区：[1]深圳市宝安区人民医院药剂科,广东深圳518101

出　　处：《亚太传统医药》2014年第21期17-20,共4页Asia-Pacific Traditional Medicine

摘　　要：目的:以马齿苋总黄酮为模型药物,制备治疗湿疹的经皮给药中药有效组分微乳。方法:通过单因素试验及伪三元相图的绘制筛选微乳组分,并以药物体外经皮渗透速率进一步优化微乳处方。结果:优选处方为肉豆蔻酸异丙酯-Cremophor EL-丙三醇-水(6.5:29.25:29.25:35),平均粒径为24.54nm;马齿苋总黄酮稳态透皮速率为114.70μg·cm-2·h-1,比原湿疹搽剂的透皮速率提高了17倍。结论:马齿苋总黄酮微乳性状均一,澄清透明,质量稳定,透皮性能好。Objective：Taking portulaca total flavone（PTF）as model drug to prepare transdermal delivery combination microemulsion used for curing eczema.Methods：Choosing microemulsion formulation by using single factor methodology and drawing pseudo-ternary phase diagram.The prescription of microemulsion was further optimized with in vitro permeation of drug.Results：The optimized prescription of microemulsion was composed of isopropyl myristate-cremophor EL-glycerol-water（6.5：29.25：29.25：35）.The appearance of the prepared microemulsion was clear with the mean diameter of 24.54 nm.The speed of PTF in COPTIDIS RHIZOMA and paeonol in vitro permeation were 114.70μg·cm^-2·h^-1 and 74.09μg·cm^-2·h^-1,which are 17 times more than former preparation liniment＇s.Conclusion：The PTF microemulsion was homogeneous,clear,translucent,stable,and highly infiltrative.

关 键 词：马齿苋总黄酮 有效组分微乳 伪三元相图 体外经皮渗透 

分 类 号：R284.2[医药卫生—中药学]