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作 者:罗伟[1] 王军英[1] 刘春雷[1] 黄超[1] 谭龙泽[1] 易慧娟[1]
出 处:《中医药导报》2015年第1期64-67,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy
基 金:湖南省儿童医院科研基金资助项目(No.201323)
摘 要:目的:观察针灸百会穴对重症手足口病SD大鼠血清D-二聚体(D-D)、神经元特异性烯醇化酶(NSE)和神经肽Y(NPY)含量变化的影响,以期寻找针灸百会穴与重症手足口病预后疗效之间的契合点,为临床应用针灸百会穴辅助治疗重症手足口病患儿、改善预后提供实验依据。方法:通过EV71型病毒驯化获取EV71高神经侵袭力毒株后,进行SD大鼠预处理确定重症手足口病SD大鼠模型,以西药、针灸百会穴为治疗方法,2周后采用放射免疫法检测D-D、NSE以及NPY水平。结果:西药组和电针、艾灸组均能降低重症手足口病SD大鼠血清中D-D、NSE以及NPY水平,电针组和艾灸组降低D-D、NSE以及NPY水平的作用优于西药组(P<0.01),表明纯西药治疗方法抑制模型鼠D-D、NSE以及NPY水平的作用低于在西药治疗的基础上加用针灸百会穴所起到的抑制作用。结论:针灸百会穴可降低重症手足口病SD大鼠血清中D-D、NSE及NPY水平;针灸百会穴辅助治疗重症手足口病的机制可能与降低血清中D-D、NSE及NPY水平有关。Objective: To observe influence of acupuncture at "'Baihui'(DU20)" on serum D-two dimers (D-D), neuron specific enolase (NSE) and neuropeptide Y (NPY) contents in SD rat with severe hand foot and mouth disease, and to find a meeting point between the acupuncture of "'Baihui'(DU20)" point and therapeutic effect of severe hand foot mouth disease, in order to provide experimental evidence for the clinical application of acupuncture at "'Baihui'(DU20)" in severe hand foot and mouth disease and improvement of the prognosis. Methods: The EV71 virus domestication gets high neural invasion of virus; SD rats pretreated with determination of severe hand foot mouth disease rat model of SD; With treatment with western medicine, acupuncture and moxibustion at "'Baihui'(DU20)" for 2 weeks,D-D, NSE and NPY levels were measured by radioimmunoassay. Results: The western medicine group, acupuncture group and moxibustion group significantly reduced serum D-D, NSE and NPY levels in SD rats with severe hand foot mouth disease, and the effect of acupuncture and moxibustion group was more significant effect (P〈0.01), which showed that the effect of western medicine treatment on inhibition of D-D, NSE and NPY levels was lower than that of Weste rnmedicine plus acupuncture at "'Baihui'(DU20)". Conclusion: Acupuncture at "'Baihui'(DU20)" treatment can reduce the serum D-D,NSE and NPY levels in SD rats with severe hand foot mouth disease. The mechanism of acupuncture at "'Baihui'(DU20)" on severe hand foot mouth disease may related to inhibition of D-D, NSE and NPY levels.
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