天麻提取物对记忆获得障碍模型小鼠胆碱能系统的影响  

Effects of Extractive from Gastrodiae Rhizoma on Cholinergic System in Mouse Memory Acquisition Barrier Model

作　　者：韩春妮[1] 何芳雁[1] 田野[1] 段小花[1] 

机构地区：[1]云南中医学院,云南昆明650500

出　　处：《中国药业》2014年第21期3-4,共2页China Pharmaceuticals

摘　　要：目的研究天麻提取物对东莨菪碱所致记忆获得障碍模型小鼠胆碱能系统的影响。方法复制东莨菪碱致小鼠记忆获得障碍模型,通过Morris水迷宫试验测定其学习记忆成绩及乙酰胆碱含量。结果天麻总提物和乙酸乙酯提取物均能明显缩短东莨菪碱所致记忆获得障碍模型小鼠的逃避潜伏期及搜索距离(P<0.05),显著增加原平台象限时间百分比和距离百分比(P<0.01),提高小鼠脑组织中的乙酰胆碱含量(P<0.01)。结论天麻提取物能明显改善模型小鼠的记忆获得能力,其作用与增强胆碱能神经系统功能有关。Objective To investigate the effects of extractive from Gastrodia Rhizoma on cholinergic system in the mouse memory acquisition barrier model induced by scopolamine. Methods The mouse memory acquisition barrier model induced by scopolamine was duplicated. The Morris water maze was used to determine the learning and memory ability, and the content of acetylcholin was detected. Results The Gastrodia total extractive and ethyl acetate could significantly shorten the escape latency and search distance in the memory acquisition barrier model mice（ P〈0. 05）; significantly increased the percentage of original platform quadrant time and distance（ P〈0. 01）; increased the acetylcholine content in the mice brain tissue（ P〈0. 01）. Conclusion The extractive from Gastrodia Rhizoa can improve the learning- memory acquisition ability in mice,its mechanism may be related with enhancing the function of cholinergic nervous system.

关 键 词：天麻 记忆获得障碍 乙酰胆碱 MORRIS水迷宫 

分 类 号：R285.5[医药卫生—中药学] R282.71[医药卫生—中医学]