头孢地尼治疗小儿轻中度社区获得性呼吸道感染160例临床评价  

Clinical Evaluation of Cefdinir for Treating 160 Children Cases of Mild and Moderate Community Acquired Respiratory Tract Infection

作　　者：袁承军[1] 

机构地区：[1]四川省绵阳市中心医院,四川绵阳621000

出　　处：《中国药业》2014年第21期28-29,共2页China Pharmaceuticals

摘　　要：目的观察并评价头孢地尼分散片治疗小儿轻中度社区获得性呼吸道感染的临床疗效。方法将320例符合诊断标准的患儿随机均分成两组,治疗组应用头孢地尼分散片9~18 mg/（kg·d）,分3次口服;对照组应用阿奇霉素干混悬剂,第1日按体重10 mg/kg顿服,第2~5日每日按体重5 mg/kg顿服。疗程5~7 d。结果治疗组治愈率明显高于对照组（83.75%比63.75%,P〈0.05）,但两组总有效率无明显差异（96.88%比90.62%,P〉0.05）。总不良反应发生率两组间差异无统计学意义（27.50%比31.88%,P〉0.05）。结论头孢地尼治疗小儿社区获得性呼吸道感染疗效明显,值得临床应用。Objective To observe and evaluate the clinical efficacy of Cefdinir Dispersible Tablets for treating mild and moderate community acquired respiratory tract infection in children. Methods 320 children patients meeting the diagnostic criteria were randomly divided into two groups. The treatment group was given oral Cefdinir Dispersible Tablets 9- 18 mg /（ kg·d）,3 times daily,while the control group was given Azithromycin Dry Suspension 10 mg / kg once daily on 1 d,then 5 mg / kg once daily on 2- 5 d. The clinical efficacy was evaluated after the treatment course of 5- 7 d. Results The cure rate of the treatment group was significantly higher than that of the control group（ 83. 75% vs. 63. 75%, P〈0. 05）. However,the total effective rate of the two groups had no statistically significant difference（ 96. 88% vs. 90. 62%, P〉0. 05）. The total incidence rate of adverse reactions also had no statistically significant difference（ 27. 50% vs. 31. 88%, P〉0. 05）. Conclusion Cefdinir has significant effect in treating community acquired respiratory infections in children and is worthy of clinical use.

关 键 词：头孢地尼 阿奇霉素 呼吸道感染 小儿 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R978.11[医药卫生—药学]