异基因造血干细胞移植后闭塞性细支气管炎综合征1例并文献复习  

A Case of Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation and Literature Review

作　　者：银雪艳[1,2] 谢白露[1] 刘丹[3] 黄振倩[3] 谭获[3] 陈文瑛[1] 肖翔林[1] 

机构地区：[1]广州医科大学附属第一医院药学部,广州510120 [2]中山大学药学院,广州510006 [3]广州医科大学附属第一医院肿瘤血液科,广州510120

出　　处：《中国药房》2014年第46期4396-4398,共3页China Pharmacy

摘　　要：目的:探讨异基因造血干细胞移植(allo-HSCT)后闭塞性细支气管炎综合征(BOS)的治疗。方法:结合文献对1例慢性粒细胞白血病患者allo-HSCT后出现BOS的治疗情况进行分析。结果:患者移植后第10个月发生BOS,予糖皮质激素、免疫抑制剂、阿奇霉素、伊马替尼联合局部使用布地奈德、复方异丙托溴铵,以及肺功能康复治疗,4周后患者病情改善。结论:伊马替尼的加入可以使allo-HSCT后出现BOS的患者获益,BOS相关机制及治疗措施需要进一步探索。OBJECTIVE： To explore the treatment for bronchiolitis obliterans syndrome （BOS） after allogeneic hematopoietic stem cell transplantation （aUo-HSCT）. METHODS： The treatment of BOS in a patient with chronic myelogenous leukemia after al- lo-HSCT was analyzed with the help of literature. RESULTS： The patient suffered from BOS 10 month after aIlo-HSCT, and re- ceived corticosteroids, immunosuppressive agents, azithromycin and imatinib combined with local application of budesonide, com- pound ipratropium bromide and pulmonary rehabilitation. The symptom was improved after 4 weeks of treatment. CONCLUSIONS： The addition of imatinib can benefit patients with BOS after allo-HSCT, and it is needed to further study on BOS mechanism and therapeutic regimen.

关 键 词：异基因造血干细胞移植 闭塞性细支气管炎综合征 伊马替尼 

分 类 号：R974[医药卫生—药品] R969.3[医药卫生—药学]