临床药师参与白血病患儿化疗后铜绿假单胞菌败血症的治疗实践  

Practice of Clinical Pharmacists Participating in the Treatment for a Child with Pseudomonas aeruginosa Septicemia after Leukemia Chemotherapy

作　　者：张文渊[1,2] 卢荣枝[2] 黄民[1] 李运景[2] 

机构地区：[1]中山大学药学院,广州510006 [2]中山市人民医院,广东中山528403

出　　处：《中国药房》2014年第46期4410-4412,共3页China Pharmacy

摘　　要：目的:为临床药师参与白血病患儿败血症治疗提供参考。方法:临床医师参与1例白血病患儿化疗后出现铜绿假单胞菌败血症的治疗实践,初始治疗应用美罗培南、替考拉宁、阿米卡星治疗,治疗1周后应用伏立康唑预防真菌感染,症状未见明显好转。临床药师参加会诊后调整给药方案为:头孢哌酮/舒巴坦钠、左氧氟沙星和米卡芬净。结果:给药方案调整4 d后患者体温恢复正常,感染指标明显好转。结论:临床药师参与可为白血病患儿败血症的治疗提供更加有效的治疗方案。OBJECTIVE： To summarize the experience of clinical pharmacists participating in the treatment for septicemia in a child with leukemia. METHODS： Clinicians participated in the treatment for a child with P aeruginosa septicemia after leukemia chemotherapy. The initial treatment regimen was meropenem, teicoplanin and amikacin; one week later, voriconazole was applied to prevent fungal infections; however, symptoms showed no significant improvement. After consultation, clinical pharmacists ad- justed the regimen as： cefoperazone/sulbactam, levofloxacin and micafungin. RESULTS： 4 days after regimen adjustment, the body temperature returned to normal, and infection was well controlled. CONCLUSIONS： The participation of clinical pharmacists can provide more effective treatment regimen for septicemia in child with leukemia.

关 键 词：临床药师 白血病 败血症 铜绿假单胞菌 

分 类 号：R978.1[医药卫生—药品] R969.3[医药卫生—药学]