肝癌相关微小RNA的研究进展  

Research progress of liver cancer-related microRNA

作　　者：邢慧慧[1] 刘晓峰[1] 刘长江[1] 

机构地区：[1]济南军区总医院消化内科,250031

出　　处：《国际肿瘤学杂志》2014年第10期764-766,共3页Journal of International Oncology

基　　金：山东省自然科学基金（ZR2011HM021）

摘　　要：微小RNA（miRNA）是一类具有转录后调节功能的非编码单链的小分子RNA,其在肿瘤形成过程中的作用已成为目前研究的热点.大量研究提示多种miRNA的异常表达参与了肝癌的发生发展,并可用于肝癌的诊断、治疗和预后评估.深入探讨miRNA与肝癌的关系及其分子机制将为肝癌的防治提供新的思路和方法.As a non-coding single-strand small RNA, microRNA （miRNA） plays an important role in post-translational regulation. Its role in tumor formation has become a study hotspot. A large body of studies in- dicate that the abnormal expression of miRNA involves in the occurrence and development of liver cancer, which can be used for the diagnosis, therapy and prognosis evaluation of liver cancer. In-depth exploration of the molecular mechanism of miRNA and the relationship between miRNA and liver cancer could provide novel i- deas and methods for the therapy and prevention of liver cancer.

关 键 词：肝肿瘤 微RNAS 治疗 

分 类 号：R735.7[医药卫生—肿瘤]