全身暴露动态吸入染毒系统的建立与评价  

Establishment and evaluation of a whole-body dynamic inhalation exposure system

作　　者：聂志勇[1] 隋昕[1] 孙晓红[1] 王小平 王永安[1] 

机构地区：[1]军事医学科学院毒物药物研究所,抗毒药物与毒理学国家重点实验室,北京100850 [2]北京八方世纪科技有限公司,北京100086

出　　处：《军事医学》2014年第10期780-783,共4页Military Medical Sciences

基　　金：国家科技重大专项资助项目(2011ZXJ09102-05C)

摘　　要：目的建立用于高毒化学品毒理学研究的全身暴露动态吸入染毒系统,并对其安全性和实用性进行评价。方法首先通过正负压保护设计及密闭性设计完成实验室的安全性、规范性建设;然后通过改进和优化暴露染毒装置的关键技术单元,考察暴露舱内气溶胶浓度与推进速率、染毒时间、不同监测点等的关系。结果与结论在正常工作状态下,实验室可以形成暴露舱、负压实验、正压保护等多重防护,实验环境安全规范;暴露舱内气溶胶浓度可实现稳定、可控、均一,空气呈动态流动性。全身暴露动态吸入染毒系统可满足高毒化学品的吸入染毒需求。Objective To establish a whole-body dynamic inhalation exposure system for toxicological studies on highly toxic chemicals, and to evaluate the safety and applicability of the system.Methods The safety and standardization of the laboratory were ensured after positive and negative pressure protection and airtight protection were finished.By modifying and optimizing the key technological units of the exposure chamber, the relationships between aerosol concentrations in the chamber and the push rate, exposure time and different monitoring points were investigated.Results and Conclusion Multi-protection was achieved, including the independent exposure chamber, negative pressure experiment and positive pressure protection under working conditions.The laboratory meets the demands of safety and specifications.The exposure aerosol concentrations in the chamber are uniform, stable and controllable while the air is dynamically flowing.The whole-body dynamic inhalation exposure system can meet the need for toxicological studies on highly toxic chemicals.

关 键 词：吸入染毒 暴露舱 气溶胶 

分 类 号：R114[医药卫生—卫生毒理学]