尿毒症继发重症甲状旁腺功能亢进症患者肺功能特征分析  

Clinical observation of pulmonary function in patients of be severe secondary hyperparathyroidism caused by uremia

作　　者：宋玉环[1] 王艺萍[1] 覃莲香[1] 赵娜[1] 肖跃飞[1] 张凌[2] 姚力[2] 

机构地区：[1]航天中心医院(北京大学航天临床医学院),北京100049 [2]中日友好医院,北京100029

出　　处：《军事医学》2014年第10期819-822,共4页Military Medical Sciences

摘　　要：目的研究尿毒症继发重症甲状旁腺功能亢进症(secondary hyperparathyroidism,SHPT)患者肺功能损害特征及其可能的相关因素。方法应用肺功能仪检测40例重症SHPT患者的肺功能,30例同期不伴有严重SHPT的维持性血透(maintenance hemodialysis,MHD)患者及30例健康体检者作为对照组,并就SHPT组肺功能指标与全段甲状旁腺激素(intact parathyroid hormone,iPTH)等临床检验指标做相关性分析。结果 SHPT组和MHD组较健康体检者、SHPT组较MHD组肺功能均明显下降(P<0.05)。SHPT组患者肺功能多项指标与血iPTH、C反应蛋白(C reactive protein,CRP)、透析龄(dialysis age)呈负相关(P<0.05),与血红蛋白(hemoglobin,Hb)、白蛋白(albumin,Alb)呈正相关(P<0.05)。结论重症SHPT患者肺功能明显异常。血iPTH、透析龄、血红蛋白、白蛋白及CRP可能是影响SHPT患者肺功能的重要因素。Objectives To evaluate the lung function in patients of severe secondary hyperparathyroidism caused by uremia and to analyze related factors.Methods The pulmonary function of 70 patients with uremia （ 40 patients with severe secondary hyperparathyroidism, 30 MHD patients without SHPT） and 30 healthy people was determined.Correlative analysis was performed between parameters such as pulmonary function indexes and clinical or laboratory parameters. Results Lung function was significantly different between patients with uremia and healthy subjects（P＆lt;0.05, respectively）. A number of lung function indicators were negatively correlated with iPTH,C reactive protein（ CRP） ,dialysis age but were positively correlated with hemoglobin （Hb） and albumin（Alb） （P ＆lt;0.05）.Conclusion Patients with SHPT show impaired lung function.IPTH, dialysis age, Hb, Alb and CRP can be used as important indicators of lung function.

关 键 词：血液透析 尿毒症 继发性甲状旁腺功能亢进症 肺功能 

分 类 号：R692.5[医药卫生—泌尿科学] R581.1[医药卫生—外科学]