多囊卵巢综合征易感基因研究进展  

Progress in predisposing genes of polycystic ovary syndrome

作　　者：谢田[1] 李海燕[2] 

机构地区：[1]大理学院临床医学院,云南省671000 [2]大理学院附属医院妇产科

出　　处：《中华临床医师杂志（电子版）》2014年第20期64-69,共6页Chinese Journal of Clinicians(Electronic Edition)

基　　金：云南省科技厅基金资助(2011FZ296)

摘　　要：多囊卵巢综合征(PCOS)是育龄期妇女常见的生殖内分泌和代谢紊乱疾病之一,是导致女性不孕最常见的原因之一,其发病机制复杂,具有多种临床表现。PCOS单卵双生子的高共患率、发病的家族聚集倾向及种族差异提示遗传易感性在其发病机制中起重要作用。近年来研究认为PCOS是一种多基因遗传性疾病,相关基因已成为研究热点。本文就近年来PCOS相关易感基因的研究进展作一综述。Polycystic ovary syndrome （PCOS） is one of the most common reproductive endocrine and metabolic disorders in women at childbearing age, which is also one of the most common causes of female infertility. Its pathogenesis is complex, associated with a variety of clinical manifestations. Epidemiology data, including family aggregation, twin studies and ethnic differences in disease prevalence indicate that genes contribute to the pathogenesis of PCOS. Recent studies suggest that PCOS is a polygenic hereditary disease and predisposing genes associated with it have become a hot topic. In this review, we discussed the progress of predisposing genes of PCOS in recent years.

关 键 词：多囊卵巢综合征 基因 多态性 单核苷酸 

分 类 号：R711.75[医药卫生—妇产科学]