人白细胞抗原-G基因多态性与单纯疱疹病毒性脑炎相关性研究  

Relationship between human leukocyte antigen-G polymorphism and risk of herpes simplex encephalitis

作　　者：柯绍发[1] 胡晓飞[1] 王凤[1] 伍嫦珠[1] 朱敏[1] 樊树峰[1] 

机构地区：[1]温州医学院附属台州医院,浙江台州317000

出　　处：《疾病监测》2014年第10期768-771,共4页Disease Surveillance

基　　金：2008年浙江省医药卫生科技计划(No.2008B193)~~

摘　　要：目的研究人白细胞抗原-G(HLA-G)基因多态性与单纯疱疹病毒性脑炎(HSE)发病风险的相关性。方法应用聚合酶链反应检测HSE患者及正常人的HLA-G基因14 bp插入/缺失(ins/del)多态性分布,分析HLA-G基因型、等位基因与HSE发病风险的关系。结果 HLA-G14 bp的3种基因型在HSE组和对照组的分布差异有统计学意义(P=0.007),并且HSE组del/del基因型频率较对照组明显升高(OR=5.56,P=0.018)。等位基因频率的分析发现HSE组14 bp缺失(-14 bp)频率较对照组高(78.70%vs.67.16%),两组差异有统计学意义(OR=1.81,P=0.004)。结论 HLA-G 14 bp插入/缺失多态性可能与HSE的发病相关,其中14 bp缺失可能是HSE发病的一个遗传危险因素。Objective To understand the relationship between human leukocyte antigen antigen-G （HLA-G） 14 bp insertion/deletion polymorphism and the risk of herpes simplex encephalitis （HSE）. Methods Polymerase chain reaction was performed to detect the HLA-G 14 bp insertion/deletion polymorphism of HSE patients and healthy controls and analyze the relationship between genotype and allele of HLA-G and risk of HSE. Results There was a significant difference in the distribution of HLA-G 14 bp genotypes between HSE patients and healthy controls （ P = 0. 007 ）. A significant increased frequency of HLA-G 14 bp del/del（59. 13% vs. 41.04%, OR =5.56, P =0. 018） was observed in HSE patients compared with the healthy controls, and the allele frequency of 14 bp deletion in HSE group outweighed that of control group （ 78. 70% vs. 67.16% ）, the difference was statistical significant （ OR = 1.81, P = 0. 004 ）. Conclusion HLA-G 14 bp insertion/deletion polymorphism might be related with HSE, and 14 bp deletion could be one of the risk genetic factors contributing to HSE.

关 键 词：人白细胞抗原-G 基因多态性 单纯疱疹病毒性脑炎 

分 类 号：R512.3[医药卫生—内科学]