同时测定工作场所空气中二甲基甲酰胺和二甲基乙酰胺的气相色谱质谱联用测定法  

Simultaneous determination of N,N-dimethylformamide and N,N-dimethylacetamide in the air of workplace by GC-MS

作　　者：刘云富[1] 谭广辉[1] 

机构地区：[1]广东省惠州市职业病防治院,516008

出　　处：《职业与健康》2014年第21期3046-3047,3050,共3页Occupation and Health

摘　　要：目的建立工作场所空气中二甲基甲酰胺（DMF）和二甲基乙酰胺（DMA）的气相色谱质谱联用测定法。方法采用多孔玻板吸收管采集,经DB-5MS毛细管色谱柱分离后气相色谱质谱联用仪测定。结果该方法 DMF和DMA的分离效果好,检出限分别为1.2和1.1μg/ml;方法的重现性好,相对标准偏差分别为1.6%-3.1%和1.8%-3.5%;平均加标回收率分别为94.2%-102.5%和92.9%-104.4%。结论该方法精确、稳定、灵敏度高,适用于工作场所空气中DMF和DMA的同时测定。[Objective]To establish the method for simultaneous determination of N,N-dimethylformamide（ DMF） and N,N-dimethylacetamide（ DMA） in the air of workplace by gas chromatography mass spectrometry（ GC-MS）. [Methods]The samples were collected by the porous glass plate absorber tubes, separated with DB-5MS capillary columns, and measured by GC-MS.[Results]It was proved that DMF and DMA were separated effectively,while the detection limit was 1. 2 μg/ml and 1. 1 μg/ml respectively. The method presented good reproducibility,the relative standard deviation（ RSD） was 1. 6%-3. 1% and 1. 8%-3. 5%respectively,and the average recovery was 94. 2%-102. 5% and 92. 9%-104. 4% respectively. [Conclusion]The proposed method has high sensitivity,and it provides an accurate and stable way for simultaneous monitoring of DMF and DMA in the air of workplace.

关 键 词：工作场所空气 二甲基甲酰胺 二甲基乙酰胺 气相色谱质谱联用测定法 

分 类 号：R134.4[医药卫生—劳动卫生]