慢性阻塞性肺疾病患者血浆血浆内皮素-1与炎性标记物的相关性研究  

Study on the relationship between the ET-1 and inflammatory markers of plasma in chronic obstructive pulmonary disease patients

作　　者：伍冬冬 曾玉兰[1] 杨荣时[1] 

机构地区：[1]华中科技大学同济医学院附属梨园医院呼吸科,武汉430077

出　　处：《临床内科杂志》2014年第9期614-616,共3页Journal of Clinical Internal Medicine

摘　　要：目的 通过观察慢性阻塞性肺疾病（COPD）急性加重期患者治疗前后血浆内皮素-1（ET-1）等炎性因子的变化,探讨其临床意义及其相互关系.方法 用ELISA法测定30例COPD急性加重期患者治疗前后血浆ET-1、降钙素基因相关肽（CGRP）的水平,半定量免疫色谱法检测血清降钙素原（PCT）水平,免疫散射比浊法检测血浆C反应蛋白（CRP）水平,同时进行血气分析,并与我院同期30例健康体检者组成的对照组进行比较.结果 COPD急性加重期组和缓解期组ET-1、PCT、CRP水平均较对照组明显升高（P＜0.01）,血浆CGRP水平较对照组明显下降（P＜0.01）;COPD缓解期组ET-1、PCT、CRP水平较急性加重期组明显下降（P＜0.01）,CGRP水平较急性加重期组明显升高（P＜0.01）.直线相关分析显示,COPD急性加重期组ET-1、PCT、CRP三者之间呈显著正相关,且均与CGRP呈显著负相关;CGRP与PaO2呈显著正相关,ET-1、CRP、PCT均与PaO2呈显著负相关.结论 联合检测ET-1、CGRP、PCT、CRP有助于COPD患者病情监测和指导治疗.Objective To explore the significance of changes and mutual relations of endothelin-1 （ ET-1 ） and inflammatory markers of plasma in chronic obstructive pulmonary disease （COPD）. Methods 30 patients with COPD were selected as actue exacerbation group. When their illness alleviated after three weeks, they were enrolled in COPD paracmasis group. 30 healthy individuals were enrolled in control group. ELISA method was used to detect the levels of ET-1, CGRP in plasma in every group, with Semi-quantitative immune chromatography assay for the level of PCT, and immune scatter turbidimetry method for the level of CRP in plasma. And synchronized arterial blood gas analysis were conducted. Results Compared with the control group,the levels of ET-1 ,CRP,PCT in both AECOPD group and paracmasis group increased significantly（P 〈0.01 ） ,while the CGRP decreased（P 〈0.01 ）. The levels of ET-1, PCT, CRP in paracmasis group were statistically lower than those in AECOPD group （ P 〈 0.01 ）, while the level of CGRP in plasma was higher than that in AECOPD group （ P 〈 0.01 ）. The linear correlation analysis showed that the levels of ET-1 ,PCT and CGRP in AECOPD group was positively correlated with eath other, and all showed negtively correlated with the CGRP. The ET-1, PCT and CGRP had a significant negative correlation with PaO2. To the contrast, the level of CGRP was postively correlated with PaO2. Conclusion The detections of these indicators might contribute to monitoring condition and guiding treatment on patients with COPD.

关 键 词：慢性阻塞性肺疾病 内皮素-1 降钙素基因相关肽 降钙素原 C反应蛋白 ENDOTHELIN-1 

分 类 号：R563.05[医药卫生—呼吸系统]