脑脊液CK-BB、IgG指数与一氧化碳中毒迟发性脑病的相关性研究  

The relevance of CSF CK-BB, IgG index and delayed encephalopathy after carbon monoxide poisoning

作　　者：王凤平[1] 张德新[1] 庞晓婷 孙辉[1] 王新春[1] 梁庆成[3] 邓颖[1] 

机构地区：[1]哈尔滨医科大学附属第二医院急诊科,黑龙江哈尔滨150086 [2]哈尔滨市红十字中心医院,黑龙江哈尔滨150086 [3]哈尔滨医科大学附属第二医院神经内科,黑龙江哈尔滨150086

出　　处：《现代预防医学》2014年第23期4403-4405,共3页Modern Preventive Medicine

基　　金：黑龙江省教育厅科学技术研究项目(12511277)

摘　　要：目的研究家兔急性一氧化碳(CO)中毒后脑脊液CK-BB、IgG指数的变化,探讨其与急性一氧化碳中毒迟发性脑病(DEACMP)的相关性。方法将中毒组家兔放入一氧化碳中毒箱内,观察家兔的中毒症状,并经尾部采血测定血液中一氧化碳血红蛋白(HbCO)浓度;分别于中毒后24 h、3 d、7 d、14 d记录各家兔行为学变化,通过迷宫实验判断是否发生DEACMP,并采集脑脊液,采耳血,检测脑脊液CK-BB及IgG指数。结果脑病组与对照组及非脑病组对比在中毒后7 d、14 d脑脊液CK-BB、IgG指数均明显升高(P<0.01)。脑病组Ig G指数在中毒后14 d升高更明显。结论脑脊液CK-BB、IgG指数升高与急性一氧化碳中毒性脑病发生成正相关,对预测一氧化碳中毒后迟发性脑病有重要意义。Objective To study the relationship of CK-BB in cerebrospinal fluid（CSF） and IgG index with delayed encephalopathy after acute carbon monoxide poisoning（DEACMP）. Methods We put the rabbits into the box with carbon monoxide, observed the symptoms of rabbits, measured carbon monoxide in the blood hemoglobin（HbCO） concentrations, and recorded the change in rabbit behavior, through the maze test to determine whether DEACMP, and detect of CK-BB and IgG index. Results After 7 days and 14 days, compared with control group and non-encephalopathy group（non-DNS group）, CSF CK-BB and IgG index of encephalopathy groups（DNS group） were significantly higher（P〈0.01）, IgG index of DNS group increased more significantly after 14 days.Conclusion CK-BB of CSF and IgG index are correlated with the occurrence of acute carbon monoxide toxic encephalopathy positively, it is important to predict DEACMP.

关 键 词：一氧化碳中毒迟发性脑病 CK-BB IGG指数 

分 类 号：R74[医药卫生—神经病学与精神病学]