β-酮酸酯类化合物与丁烯酮的Micheal加成反应研究  

Michael Addition Reaction of β-Keto Esters and Methyl Vinyl Ketone

作　　者：李晨辉[1] 鲍莹[1] 张辉[1] 刘建宇[1] 许永男[1] 

机构地区：[1]沈阳药科大学教育部基于靶点的药物设计与研究重点实验室,辽宁沈阳110016

出　　处：《辽宁化工》2014年第10期1236-1237,共2页Liaoning Chemical Industry

摘　　要：2-氧代环戊烷甲酸甲酯或2-氧代环己烷甲酸甲酯与短链α,β-不饱和羰基化合物丁烯酮在六水合三氯化铁催化、无溶剂条件下进行Michael加成反应,能有效避免副反应的发生。该方法也可应用于其他β-酮酸酯类化合物,反应简便易行,收率高。所得到化合物结构均经1H-NMR和MS谱确证。Using ferric chloride hexahydrate as the catalyst, the Michael addition reaction between esters of 2-oxocyclopentanecarboxylic acid and short chain α,β-unsaturated carbonyl compound under solvent free conditions was carried out, the side reactions were effectively avoided. And the product was characterized by 1H-NMR and mass spectrometry. The method has simple operation and high yield.

关 键 词：Β-酮酸酯 Micheal加成反应 Α Β-不饱和酮 

分 类 号：TQ234[化学工程—有机化工]