心舒宝对大鼠血糖血脂的调节作用  

Role of Xinshubao in Regulation of Blood Glucose and Lipid in Rats

作　　者：李艳梅[1,2,3,4] 李英镇 李昀健 陈叙伟 

机构地区：[1]暨南大学再生医学教育部重点实验室,广东广州510632 [2]科技部及广东省科技厅"国际科技合作基地",广东广州510632 [3]再生医学联合实验室(暨南大学-香港中文大学),广东广州510632 [4]暨南大学发育与再生生物学系,广东广州510632

出　　处：《时珍国医国药》2014年第11期2644-2646,共3页Lishizhen Medicine and Materia Medica Research

基　　金：福建省科技重点项目(No.2011Y5003)

摘　　要：目的探究心舒宝对大鼠血糖、血脂的调节作用。方法正常雌、雄性SD大鼠分别灌喂不同剂量心舒宝药物,观察心舒宝对大鼠血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)以及血糖的影响;建立大鼠高血脂模型分3组:对照组(高脂饲料)、实验组1(普通饲料+心舒宝)、实验组2(高脂饲料+心舒宝),灌药4周后取血测定上述指标。结果心舒宝能明显上调正常雌性大鼠的HDL-C(P<0.05),对TC、TG和LDL-C没有明显下调作用(P﹥0.05),能够下调正常雄性大鼠TG、LDL-C(P<0.05);心舒宝能够明显下调高血脂大鼠的TC(P<0.01)、LDL-C含量(P<0.05)。结论心舒宝能够降低大鼠高血脂,能提升正常大鼠HDL-C含量,能够降血糖,具有潜在的保健作用。Objective To explore the effects of Xinshubao on blood glucose and lipid in rat. Methods Female male SD rats were fed with different doses of Xinshubao respectively,research the effect of Xinshubao on serum cholesterol（TC）,triglyceride（TG） 、high density lipoprotein cholesterol（HDL-C） 、low density lipoprotein cholesterol（LDL-C） and blood glucose. The rat model of hyperlipemia were randomly divided into three groups：control group was fed with high fat diet,experiment 1 group was fed with normal diet and gavaged with Xinshubao,and experiment 2 group was fed with high fat diet and gavaged with Xinshubao.Four weeks later,blood samples were collected to examine the levels of TG,TC,HDL,LDL and blood glucose suing kits. Results（1） Xinshubao can significantly increase HDL-C（P〈0. 05） on female rats,the effect for TC,TG and LDL-C was not significantly; It had significant effects on the levels of TG,LDL-C in male rats（P〈0. 05）; For hyperlipidemia rats,Xinshubao can decrease the level of TC（P〈0. 01） and LDL-C in females significantly（P〈0. 05）. Conclusion Xinshubao can reduce high blood Lipids,and can enhance the normal rat HDL-C levels,while being able to decrease blood glucose level,it has potential health effects.

关 键 词：心舒宝 血糖 血脂 

分 类 号：R285.5[医药卫生—中药学]