银屑灵片处方优化的实验研究  

Optimization of Yinxieling Capsule with orthogonal design

作　　者：闫玉红 赵瑞芝 卢传坚 

机构地区：[1]广州中医药大学第二附属医院,广东广州510120

出　　处：《时珍国医国药》2014年第11期2673-2675,共3页Lishizhen Medicine and Materia Medica Research

基　　金：广东省自然科学基金课题(No.7004847;S2011040003130);广东省财政厅课题(No.2011KT1887);中国博士后科学基金(No.2012M511783)

摘　　要：目的对银屑灵片处方进行配伍筛选,寻找最佳处方组成。方法对处方中药物,采用正交设计的方法,选择L12(211)正交实验表安排实验,选择银屑灵片拆方后各组药物对低分子右旋糖酐-40制备的小鼠瘙痒模型的影响和银屑灵片拆方后各组药物对小鼠鼠尾鳞片表皮颗粒层形成的影响作为主要药效指标,进行组方配伍的初步筛选。结果根据正交拆方后实验结果,银屑灵片拆方中止痒的最优组合为乌梅、甘草、紫草、金粟兰、土茯苓;促进小鼠鼠尾鳞片表皮颗粒层形成的最优组合是赤芍、土茯苓、莪术。综合两组实验结果,确立银屑灵片优化方处方组成为:赤芍、莪术、乌梅、紫草、金粟兰、土茯苓、甘草。结论银屑灵片具有止痒及促进小鼠鼠尾鳞片表皮颗粒层形成的作用,以此为病理模型筛选出的"银屑灵片优化方"药简而力宏,具有进一步深入研究的潜力和价值。Objective To find the optimal prescription of Yinxieling Capsule. Methods To optimize Yinxie Ling Capsule with orthogonal design. Twelve experiments groups were carried out by L12（2^11） orthogonal table. Each group were given itching model and mouse tail model as filters＇ experiments. Sieved the best optimization named the Optimization of Yin Xie Ling Capsule. Results The Optimization of Yinxieling Capsule is made up of Radix Paeoniae Rubra,Fructus Mume,Rhizoma Curcumae,Glabrous Greenbrier Rhizome,Radix Paeoniae Rubra,Chloranthus spicatus（Thunb.） Makino,Radix Glycyrrhiza. Conclusion Yinxieling Capsule has better alleviating itching effect and significantly promoted the formation of granular cell of mouse tail. The Optimization of Yin Xie Ling Capsule has less drug but same effects.

关 键 词：银屑病 银屑灵片 处方优化 银屑灵片优化方 

分 类 号：R283[医药卫生—中药学]