噻酰菌胺的清洁化工艺  

The Clean Process of Tiadinil

作　　者：李爱军[1] 武杰[1] 靳淑委[2] 

机构地区：[1]河北科技大学化学与制药工程学院,石家庄050018 [2]石家庄科技信息职业学院医药化工系,石家庄050091

出　　处：《农药》2014年第12期872-874,877,共4页Agrochemicals

摘　　要：[目的]噻酰菌胺是一种新型杀菌剂,对其合成工艺进行优化改进,重点探讨4-甲基-1,2,3-噻二唑-5-甲酸甲酯与3-氯-4-甲基苯胺直接酰胺化的清洁化工艺。[方法]以乙酰乙酸甲酯为原料,经缩合、关环、酰胺化反应3步合成噻酰菌胺。[结果]在优化的反应条件下,总收率70.4%,纯度98.5%。[结论]该工艺缩短了生产步骤,减少了废水和废气的排放,适合工业化生产。[Aims] Tiadinil is a novel fungicide. This paper aims to optimize and improve the synthetic process,especially to discuss the clean process of amidation between methyl 4-methyl-1,2,3-thiadiazole-5-carboxylate and3-chloro-4-methylaniline. [Methods] Tiadinil was synthesized from methyl acetoacetate through the process of condensation, cyclization and amidation. [Results] Under the optimal conditions, the total yield was 70.4% based on methyl acetoacetate and the purity was 98.5%. [Conclusions] The process shortened the reaction steps and has low exhaust of waste gas and waste water, which is suitable for industrial manufacture.

关 键 词：噻酰菌胺 杀菌剂 合成 

分 类 号：TQ455[化学工程—农药化工]