呼吸系统疾病风热犯肺证生物样本特征  

Study on Biological Samples of Wind-Heat Invading Lung Syndrome In Respiratory System Diseases

作　　者：常艳鹏[1,2] 王连心[1] 谢雁鸣[1] 尤丽[3] 卢鹏飞[1] 

机构地区：[1]中国中医科学院中医临床基础医学研究所 [2]沈阳市骨科医院 [3]中国人民大学

出　　处：《中医杂志》2014年第23期2048-2051,共4页Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药行业科研专项(200907001-5-6)

摘　　要：目的研究呼吸系统疾病风热犯肺证和非风热犯肺证生物样本的差异。方法采用多中心、大样本、前瞻性的研究方法,对1136例入院诊断为上呼吸道感染及肺炎的患者中医辨证为风热犯肺证(885例)和非风热犯肺证(251例),采集血液样本检测白细胞介素1β(IL-1β)、白细胞介素4(IL-4)、白细胞介素6(IL-6)、白细胞介素8(IL-8)、环磷酸腺苷(c AMP)、巨噬细胞炎性蛋白1β(MIP-1β)、前列腺素E2(PGE2)、肿瘤坏死因子-α(TNF-α)含量,并采用倾向性评分的方法对两组中的混杂因素进行平衡,采用带协变量调整的倾向性评分加权Logistic回归方法比较风热犯肺证是否对各项检测指标产生影响。结果上呼吸道感染及肺炎的风热犯肺证患者与非风热犯肺证患者比较,血清IL-1β、IL-4、IL-6、IL-8、c AMP、MIP-1β、PGE2、TNF-α指标含量均明显升高(P<0.01);采用倾向性评分加权结合协变量调整的统计学方法控制混杂因素,结果显示风热犯肺证对IL-1β、IL-4、IL-6、IL-8、c AMP、MIP-1β、PGE2、TNF-α均具有明显的影响(P<0.05)。结论呼吸系统疾病发病早期,风热犯肺证与非风热犯肺证相比,患者生物样本指标呈现一定的差异。Objective To study on the differences of biological samples between wind-heat invading lung syndrome and non wind-heat invading lung syndrome of diseases in respiratory system. Methods A multi-center, large sample, prospective research method was launched. We used syndrome differentiation to diagnose patients with wind-heat invading lung syndrome （885 cases） and non wind-heat invading lung syndrome （251 cases） out of 1 136 patient who was admitted as upper respiratory tract infection or pneumonia, then took blood samples to detect interleu- kin 1 -3 （ IL-1 [5）, interleukin 4 （ IL-4）, interleukin 6 （ IL-6 ）, interleukin 8 （ IL-8 ）, cyclic adenosine monophos- phate （ cAMP）, maerophage ＂inflammatory protein 1 β（ MIP-1 β）, prostaglandin E2 （ PGE2 ）, tumor necrosis factora （TNF-a）. Then propensity scoring was applied to balance confounding factors in these two groups and the method of propensity score weighted Logistic regression with adjusted covariate was used to determine whether wind-heat invading lung syndrome had an impact on each test result. Results Comparing wind-heat invading lung syndrome with non wind-heat invading lung syndrome in upper respiratory tract infection and pneumonia, IL-Iβ, IL-4, IL-6, IL-8, cAMP, MIP-1 β, PGE2, and TNF-a in blood serum were notedly increased and the differences showed statistical sig- nificance （ P 〈 0. 01 ）. With statistic method of propensity score weighted with adjusted covariate adopted to control confounding factors, results suggested that wind-heat invading lung syndrome had a great impact on IL-1 β, IL-4, IL- 6, IL-8, cAMP, MIP-1 β, PGE2 , TNF-a, which had statistical significance （P 〈 0. 05）. Conclusion On early stage of respiratory system disease, we find certain differences of patients＇ biological sample when comparing windheat invading lung syndrome with non wind-heat invading lung syndrome.

关 键 词：上呼吸道感染 肺炎 风热犯肺证 白细胞介素 炎症因子 

分 类 号：R259[医药卫生—中西医结合]