显微损伤修复过程中骨组织纳米力学性能的变化  

Variation of Nano-Mechanical Property During the Repair of Microdamage

作　　者：王刚[1,2] 于志锋[1] 

机构地区：[1]上海市骨科内植物重点实验室,上海交通大学医学院附属第九人民医院,上海200011 [2]南京医科大学第二附属医院骨科,南京210011

出　　处：《上海交通大学学报》2014年第5期730-734,740,共6页Journal of Shanghai Jiaotong University

基　　金：国家青年自然科学基金(11002090);上海市自然科学基金(10ZR1417900)资助项目

摘　　要：人工关节置换、骨折内固定等骨科植入物手术会在其周围造成显微损伤,这些机械性显微损伤会降低植入物周围骨的质量,影响其与植入物界面之间的结合强度,并进而影响植入物的长期稳定性.通过在山羊胫骨植入螺钉建立显微损伤模型,比较螺钉植入近端和远端两种不同情况下机械性显微损伤的产生和修复,以及修复过程中骨微观力学性能和骨组织元素成分的变化.结果发现:显微损伤产生和修复过程中,局部骨组织的硬度和弹性模量都呈现下降趋势;随着显微损伤修复的逐渐完成,其微观力学性能又有所恢复.The replacement of artificial joints, the internal fixation of fracture and other orthopedic im- plants will cause microdamage in the bone around the implant. Microdamage will reduce the bone quality around the implant, and affect the bonding strength within the interface between the implant and the bone, thus influencing the long-term stability of the implant. In this paper, the production and repair of proximal and distal mechanical microdamage after the implantation of screws, as well as variations in the microme- chanical property and composition elements of bone tissue were compared during the process of mierodam- age repair. It is found that with the repair of microdamage, there is a decrease both in the hardness and elastic modulus of local bones. With the final repair of microdamage, the micromechanical properties are restored.

关 键 词：显微损伤 内植物 纳米压痕 骨重建 

分 类 号：R318.01[医药卫生—生物医学工程]